Suzanna Ndraha1. 1. Department of Internal Medicine, Koja Hospital, Tanjung Priok, Jakarta Utara, Indonesia. susan_ndraha@yahoo.co.id
Abstract
AIM: to evaluate the efficacy of combination of PPI with prokinetic drug compared to PPI mono therapy in GERD patients with high frequency scale for the symptoms of GERD (FSSG) score. METHODS:sixty dyspeptic patients having heartburn and/or regurgitation were recruited during the period of July 2010-April 2011 in this double blind clinical trial. By randomization, they were divided into two groups; group A was given omeprazole 2 x 20 mg and domperidone 3 x 10 mg for 2 weeks, while another group was only given omeprazole 2 x 20 mg. The FSSG score was performed before treatment and after 2 weeks of treatment. RESULTS:there were 20 (33%) males and 40 (67%) females. The mean total score of FSSG was 25.3 ± 8.2 at pretest, and 19.3 ± 9.7 at posttest, with improvement of 6.1 ± 4.9. The FSSG score in group A after treatment (19.3 ± 11.3) was significantly lower than before treatment (26.7 ± 8.9, p<0.001) as well as in group B (from 23.9 ± 7.3 to 19,3 ± 7.9, p<0.001). The mean improvement score in group A was 7.5 ± 5.9, while in the group B was of 4.6 ± 3.3, and this difference was statistically significant (p=0.02) CONCLUSION: combination of omeprazole with domperidone in GERD patients with high FSSG score is more superior compared to omeprazole monotherapy.
RCT Entities:
AIM: to evaluate the efficacy of combination of PPI with prokinetic drug compared to PPI mono therapy in GERDpatients with high frequency scale for the symptoms of GERD (FSSG) score. METHODS: sixty dyspeptic patients having heartburn and/or regurgitation were recruited during the period of July 2010-April 2011 in this double blind clinical trial. By randomization, they were divided into two groups; group A was given omeprazole 2 x 20 mg and domperidone 3 x 10 mg for 2 weeks, while another group was only given omeprazole 2 x 20 mg. The FSSG score was performed before treatment and after 2 weeks of treatment. RESULTS: there were 20 (33%) males and 40 (67%) females. The mean total score of FSSG was 25.3 ± 8.2 at pretest, and 19.3 ± 9.7 at posttest, with improvement of 6.1 ± 4.9. The FSSG score in group A after treatment (19.3 ± 11.3) was significantly lower than before treatment (26.7 ± 8.9, p<0.001) as well as in group B (from 23.9 ± 7.3 to 19,3 ± 7.9, p<0.001). The mean improvement score in group A was 7.5 ± 5.9, while in the group B was of 4.6 ± 3.3, and this difference was statistically significant (p=0.02) CONCLUSION: combination of omeprazole with domperidone in GERDpatients with high FSSG score is more superior compared to omeprazole monotherapy.
Authors: Anna Maria Caruso; Maria Rita Di Pace; Pieralba Catalano; Fabiana Farina; Alessandra Casuccio; Marcello Cimador; Enrico De Grazia Journal: Pediatr Surg Int Date: 2013-04-10 Impact factor: 1.827