Clonidine challenge testing of alpha-2-adrenoceptor function in man: the effects of mental illness and psychotropic medication.

The clonidine challenge test is a means of assessing alpha-2-adrenoceptor sen sitivity in man. We review studies which have used this test to investigate central alpha-2- adrenoceptor changes in psychiatric illness, and to determine receptor changes after adminis tration and withdrawal of psychotropic treatments. Patients with severe depression show evidence of reduced alpha-2-adrenoceptor sensitivity, especially a reduced growth hormone response to clonidine. This may delineate a subgroup of patients with severe depressive illness from those with milder depression, and may even provide a trait marker for some depressed patients. Patients with panic disorder show evidence of subsensitivity to some and supersensitivity to other clonidine-induced responses. Other disorders, although less well investigated, may have abnormal test responses which may provide additional information about their cause and treatment. Changes in response after drug treatment have provided important information on the mode of action of antidepressants, and have suggested that noradrenergic function is altered by a variety of different antidepressants.