BACKGROUND/AIMS: Despite all the knowledge about gastric cancer, there is no prognostic biomarker which could be useful for early detection. Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway. DKK-1 is reported to be over expressed in many malignant tissues. The purpose of this study was to elucidate the normal level of serum DKK-1 (sDKK-1) levels in healthy Turkish peoples and to investigate the clinical utility of sDKK-1 levels for gastric cancer screening. METHODOLOGY: Serum DKK-1 levels were measured in 69 healthy controls and in 60 gastric adenocarcinoma patients with ELISA and sDKK-1 levels were compared with clinicopathological features and outcomes in gastric cancer patients. RESULTS: Serum concentrations of DKK-1 in gastric adeno cancer patients were significantly higher than control patients (p<0.001). The optimal cut-off for sDKK-1 levels order to discriminate control group from gastric cancer patients was 25U/mL with sensitivity equal to 100% and specificity equal to 100%. CONCLUSIONS: Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers.
BACKGROUND/AIMS: Despite all the knowledge about gastric cancer, there is no prognostic biomarker which could be useful for early detection. Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway. DKK-1 is reported to be over expressed in many malignant tissues. The purpose of this study was to elucidate the normal level of serum DKK-1 (sDKK-1) levels in healthy Turkish peoples and to investigate the clinical utility of sDKK-1 levels for gastric cancer screening. METHODOLOGY: Serum DKK-1 levels were measured in 69 healthy controls and in 60 gastric adenocarcinomapatients with ELISA and sDKK-1 levels were compared with clinicopathological features and outcomes in gastric cancerpatients. RESULTS: Serum concentrations of DKK-1 in gastric adeno cancerpatients were significantly higher than control patients (p<0.001). The optimal cut-off for sDKK-1 levels order to discriminate control group from gastric cancerpatients was 25U/mL with sensitivity equal to 100% and specificity equal to 100%. CONCLUSIONS: Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers.
Authors: N J Shimwell; D G Ward; Y Mohri; T Mohri; L Pallan; M Teng; Y C Miki; M Kusunoki; O Tucker; W Wei; J Morse; P J Johnson Journal: Br J Cancer Date: 2012-09-11 Impact factor: 7.640
Authors: Lin Wang; Xiao Bo Hu; Wei Zhang; Lin Di Wu; Yu Sheng Liu; Bo Hu; Cheng Long Bi; Yi Fei Chen; Xin Xin Liu; Cheng Ge; Yun Zhang; Mei Zhang Journal: PLoS One Date: 2013-01-24 Impact factor: 3.240
Authors: Patrizia D'Amelio; Ilaria Roato; Marco Oderda; Francesco Soria; Andrea Zitella; Riccardo Ferracini; Giulio Mengozzi; Paolo Gontero; Giovanni Carlo Isaia Journal: BMC Clin Pathol Date: 2014-03-21