Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.

Literature DB >> 22155827

Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.

Jessica A Belser¹, Katrina Sleeman, Melissa B Pearce, Jacqueline M Katz, Larisa V Gubareva, Terrence M Tumpey.

Abstract

The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 22155827 PMCID： PMC3294944 DOI： 10.1128/AAC.06101-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

25 in total

Review 1. Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors.

Authors: M Tisdale
Journal: Rev Med Virol Date: 2000 Jan-Feb Impact factor: 6.989

2. Phylogenetic analysis of H7 haemagglutinin subtype influenza A viruses.

Authors: J Banks; E C Speidel; J W McCauley; D J Alexander
Journal: Arch Virol Date: 2000 Impact factor: 2.574

3. Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection.

Authors: Jessica A Belser; Hui Zeng; Jacqueline M Katz; Terrence M Tumpey
Journal: J Infect Dis Date: 2011-01-01 Impact factor: 5.226

4. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.

Authors: J M Woods; R C Bethell; J A Coates; N Healy; S A Hiscox; B A Pearson; D M Ryan; J Ticehurst; J Tilling; S M Walcott
Journal: Antimicrob Agents Chemother Date: 1993-07 Impact factor: 5.191

5. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.

Authors: Terrence M Tumpey; Adolfo García-Sastre; Andrea Mikulasova; Jeffery K Taubenberger; David E Swayne; Peter Palese; Christopher F Basler
Journal: Proc Natl Acad Sci U S A Date: 2002-10-04 Impact factor: 11.205

6. Inhibition of replication of avian influenza viruses by the neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid.

Authors: L V Gubareva; C R Penn; R G Webster
Journal: Virology Date: 1995-10-01 Impact factor: 3.616

7. Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus.

Authors: L V Gubareva; M N Matrosovich; M K Brenner; R C Bethell; R G Webster
Journal: J Infect Dis Date: 1998-11 Impact factor: 5.226

8. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.

Authors: Ron A M Fouchier; Peter M Schneeberger; Frans W Rozendaal; Jan M Broekman; Stiena A G Kemink; Vincent Munster; Thijs Kuiken; Guus F Rimmelzwaan; Martin Schutten; Gerard J J Van Doornum; Guus Koch; Arnold Bosman; Marion Koopmans; Albert D M E Osterhaus
Journal: Proc Natl Acad Sci U S A Date: 2004-01-26 Impact factor: 11.205

9. Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands.

Authors: Marion Koopmans; Berry Wilbrink; Marina Conyn; Gerard Natrop; Hans van der Nat; Harry Vennema; Adam Meijer; Jim van Steenbergen; Ron Fouchier; Albert Osterhaus; Arnold Bosman
Journal: Lancet Date: 2004-02-21 Impact factor: 79.321

10. Human illness from avian influenza H7N3, British Columbia.

Authors: S Aleina Tweed; Danuta M Skowronski; Samara T David; Andrew Larder; Martin Petric; Wayne Lees; Yan Li; Jacqueline Katz; Mel Krajden; Raymond Tellier; Christine Halpert; Martin Hirst; Caroline Astell; David Lawrence; Annie Mak
Journal: Emerg Infect Dis Date: 2004-12 Impact factor: 6.883

7 in total

Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route.

Review 1. Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors.

2. Phylogenetic analysis of H7 haemagglutinin subtype influenza A viruses.

3. Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection.

4. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.

5. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.

6. Inhibition of replication of avian influenza viruses by the neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid.

7. Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus.

8. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.

9. Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands.

10. Human illness from avian influenza H7N3, British Columbia.

1. Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses.

2. Reduction of Neuraminidase Activity Exacerbates Disease in 2009 Pandemic Influenza Virus-Infected Mice.

Review 3. Mammalian models for the study of H7 virus pathogenesis and transmission.

Review 4. Ocular tropism of respiratory viruses.

5. Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.

Review 6. The eyes have it: influenza virus infection beyond the respiratory tract.

Review 7. The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection.