| Literature DB >> 22155622 |
Fabrício Freire de Melo1, Andreia Maria Camargos Rocha, Gifone Aguiar Rocha, Silvia Helena Sousa Pietra Pedroso, Sérgio de Assis Batista, Lúcia Porto Fonseca de Castro, Simone Diniz Carvalho, Paulo Fernando Souto Bittencourt, Celso Afonso de Oliveira, Rodrigo Corrêa-Oliveira, Dulciene Maria Magalhães Queiroz.
Abstract
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T(reg) cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T(reg)-associated cytokines of children and adults. IL-6, IL-10 and TGF-β1 levels and Foxp3(+) cell numbers were higher, but IL-1β, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T(reg) instead of Th17 cell response to H. pylori-infection predominates in children. Copyright ÂEntities:
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Year: 2011 PMID： 22155622 DOI： 10.1016/j.micinf.2011.11.008
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700