BACKGROUND: We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF). METHODS: Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF. RESULTS: After initial increasing trend of NT-proBNP at 6 weeks in HFREF patients, there was a subsequent decrease at 12 weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12 weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12 weeks of BB up-titration. CONCLUSIONS: After 12 weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF.
RCT Entities:
BACKGROUND: We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF). METHODS: Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF. RESULTS: After initial increasing trend of NT-proBNP at 6 weeks in HFREF patients, there was a subsequent decrease at 12 weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12 weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12 weeks of BB up-titration. CONCLUSIONS: After 12 weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF.
Authors: Frank Kramer; Javed Butler; Sanjiv J Shah; Christian Jung; Savina Nodari; Stephan Rosenkranz; Michele Senni; Luke Bamber; Stephan Cichos; Chrysanthi Dori; Toeresin Karakoyun; Gabriele Jenny Köhler; Kinjal Patel; Paolo Piraino; Thomas Viethen; Praneeth Chennuru; Ayse Paydar; Jason Sims; Richard Clark; Rob van Lummel; Alexandra Müller; Chad Gwaltney; Salko Smajlovic; Hans-Dirk Düngen; Wilfried Dinh Journal: Digit Biomark Date: 2020-06-30
Authors: Brian Kerr; Rebabonye B Pharithi; Matthew Barrett; Carmel Halley; Joe Gallagher; Mark Ledwidge; Kenneth McDonald Journal: Int J Heart Fail Date: 2021-02-25
Authors: Julio A Chirinos; Mayank Sardana; Garrett Oldland; Bilal Ansari; Jonathan Lee; Anila Hussain; Anique Mustafa; Scott R Akers; Wen Wei; Edward G Lakatta; Olga V Fedorova Journal: ESC Heart Fail Date: 2018-07-03