| Literature DB >> 2215528 |
J Gajewska1, M Szczypka, B Tudek, T Szymczyk.
Abstract
The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest.Entities:
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Year: 1990 PMID： 2215528 DOI： 10.1016/0027-5107(90)90124-m
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433