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Literature DB >> 221549

Alpha-1-antitrypsin deficiency and hepatocellular carcinoma.

Abstract

Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC cells. One-quarter of HCCs, however, contained cells which showed diffuse cytoplasmic staining for AAT, a pattern seen also in the non-neoplastic livers.

Entities: Disease Gene

Mesh：

Year: 1979 PMID： 221549 PMCID： PMC1145675 DOI： 10.1136/jcp.32.4.373

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

16 in total

1. Alpha1-antitrypsin, protein marker in oral contraceptive-associated hepatic tumors.

Authors: P E Palmer; W M Christopherson; H J Wolfe
Journal: Am J Clin Pathol Date: 1977-12 Impact factor: 2.493

2. Cirrhosis and malignant hepatoma in alpha 1-antitrypsin deficiency.

Authors: S Eriksson; I Hägerstrand
Journal: Acta Med Scand Date: 1974-06

3. An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine.

Authors: J F Kerr
Journal: Pathology Date: 1969-04 Impact factor: 5.306

4. Liver disease in adults with alpha-1 -antitrypsin deficiency.

Authors: N O Berg; S Eriksson
Journal: N Engl J Med Date: 1972-12-21 Impact factor: 91.245

5. The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.

Authors: L A Sternberger; P H Hardy; J J Cuculis; H G Meyer
Journal: J Histochem Cytochem Date: 1970-05 Impact factor: 2.479

6. Alpha-antitrypsin deposition in primary hepatic carcinomas.

Authors: P E Palmer; H J Wolfe
Journal: Arch Pathol Lab Med Date: 1976-05 Impact factor: 5.534

7. Aetiology of cirrhosis, hepatic fibrosis, and hepatocellular carcinoma.

Authors: W K Blenkinsopp; G P Haffenden
Journal: J Clin Pathol Date: 1977-06 Impact factor: 3.411

8. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency.

Authors: H W Gordon; J Dixon; J C Rogers; C Mittman; J Lieberman
Journal: Hum Pathol Date: 1972-09 Impact factor: 3.466

9. Heterozygous alpha 1-antitrypsin deficiency and cirrhosis in adults, a fortuitous association.

Authors: T Morin; J P Martin; G Feldmann; B Rueff; J P Benhamou; C Ropartz
Journal: Lancet Date: 1975-02-01 Impact factor: 79.321

10. alpha 1-antitrypsin phenotypes in fibrosing alveolitis and rheumatoid arthritis.

Authors: D M Geddes; M Webley; D A Brewerton; C W Turton; M Turner-Warwick; A H Murphy; A M Ward
Journal: Lancet Date: 1977-11-19 Impact factor: 79.321

5 in total

1. Hepatoma.

Authors:
Journal: West J Med Date: 1980-06

2. [Alpha 1-antitrypsin deficiency: a review with special reference to the significance of heterozygous deficiency].

Authors: M Schneider; G Pott; U Gerlach
Journal: Klin Wochenschr Date: 1986-03-03

3. Demonstration of alpha 1-antitrypsin in paraffin sections of hepatoma and cirrhosis.

Authors: L Nakopoulou; G Theodoropoulos; L Kotsis; N Papacharalampous
Journal: Virchows Arch A Pathol Anat Histol Date: 1982

4. Alpha-1-antitrypsin and the liver: a routine immunohistological screen.

Authors: J M Theaker; K A Fleming
Journal: J Clin Pathol Date: 1986-01 Impact factor: 3.411

5. Alpha 1-antitrypsin levels and phenotypes and hepatitis B serology in liver cancer.

Authors: L Sparos; Y Tountas; C Chapuis-Cellier; G Theodoropoulos; D Trichopoulos
Journal: Br J Cancer Date: 1984-05 Impact factor: 7.640

5 in total