| Literature DB >> 22154086 |
Alessio Giubellino1, Girma M Woldemichael, Carole Sourbier, Martin J Lizak, James F Powers, Arthur S Tischler, Karel Pacak.
Abstract
Pheochromocytoma is the most common tumor of the adrenal medulla in adults. The lack of sensitive animal models of pheochromocytoma has hindered the study of this tumor and in vivo evaluation of antitumor agents. In this study we generated two sensitive luciferase models using bioluminescent pheochromocytoma cells: an experimental metastasis model to monitor tumor spreading and a subcutaneous model to monitor tumor growth and spontaneous metastasis. These models offer a platform for sensitive, non-invasive and real-time monitoring of pheochromocytoma primary growth and metastatic burden to follow the course of tumor progression and for testing relevant antitumor treatments in metastatic pheochromocytoma. Published by Elsevier Ireland Ltd.Entities:
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Year: 2011 PMID： 22154086 PMCID： PMC3253957 DOI： 10.1016/j.canlet.2011.10.019
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679