BACKGROUND: Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. HYPOTHESIS: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. ANIMALS: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. METHODS: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. RESULTS: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R(2) = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R(2) = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. CONCLUSIONS AND CLINICAL IMPORTANCE: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.
BACKGROUND:Cardiovascular disease is associated with endothelial dysfunction in humans and studies of plasma biomarkers suggest that dogs with myxomatous mitral valve disease (MMVD) might also have endothelial dysfunction. HYPOTHESIS: That progression of mitral regurgitation (MR) is associated with development of endothelial dysfunction. ANIMALS: Forty-three Cavalier King Charles Spaniels (CKCS) with MR of varying severity. METHODS: Privately owned CKCS were prospectively recruited and divided in 4 groups: (1) 12 CKCS with minimal MR; (2) 9 CKCS with mild MR; (3) 11 CKCS with moderate-severe MR; and (4) 11 CKCS with moderate-severe MR and clinical signs compatible with heart failure. Dogs underwent blood sampling, echocardiography, blood pressure (BP) recordings, and flow-mediated vasodilation (FMD) measurements. The effect of progressive MR on FMD was determined by multivariate analyses. RESULTS: Flow-mediated vasodilation decreased with progression of MR. Group 4 (4.79 ± 3.22%) had significantly lower FMD than groups 1 (10.40 ± 4.58%) and 2 (10.14 ± 3.67%) (P < .005) and group 3 (6.79 ± 3.98%) had a significantly lower FMD than group 1 (P = .03). Increasing left ventricular end-diastolic diameter (P = .0004, R(2) = 0.27) and the combination of age (P = .01) and body weight (P = .002) (R(2) = 0.31) were significantly associated with reduced FMD. FMD did not correlate with sex, BP, or plasma markers. CONCLUSIONS AND CLINICAL IMPORTANCE: Reduced FMD indicates that increased disease severity in CKCS with MMVD is associated with development of endothelial dysfunction which might be a future therapeutic and/or diagnostic target.
Authors: Trine P Ludvigsen; Niels Wiinberg; Christina J Jensen; Annemette T Callesen; Regitze W Andersen; Anne Sofie H Jørgensen; Berit Ø Christoffersen; Henrik D Pedersen; Sophia G Moesgaard; Lisbeth H Olsen Journal: Comp Med Date: 2014-12 Impact factor: 0.982
Authors: Harrie C M Boonen; Sophia G Moesgaard; Malene M Birck; Berit O Christoffersen; Susanna Cirera; Peter M H Heegaard; Tina Rødgaard Højbøge; Lars J Jensen; Alan Mortensen; Lisbeth Høier Olsen; Majid Sheykhzade; Jiaowei Tang; Jens Lykkesfeldt Journal: Pflugers Arch Date: 2014-03-05 Impact factor: 3.657
Authors: Susanna Cirera; Sophia G Moesgaard; Nora E Zois; Nathja Ravn; Jens P Goetze; Signe E Cremer; Tom Teerlink; Páll S Leifsson; Jesper L Honge; J Michael Hasenkam; Lisbeth H Olsen Journal: Endocr Connect Date: 2013-09-24 Impact factor: 3.335
Authors: M J Reimann; J Häggström; A Mortensen; J Lykkesfeldt; J E Møller; T Falk; L H Olsen Journal: J Vet Intern Med Date: 2014 Sep-Oct Impact factor: 3.333
Authors: C E Rasmussen; T Falk; A Domanjko Petrič; M Schaldemose; N E Zois; S G Moesgaard; B Ablad; H Y Nilsen; I Ljungvall; K Höglund; J Häggström; H D Pedersen; J M Bland; L H Olsen Journal: J Vet Intern Med Date: 2014-01-13 Impact factor: 3.333
Authors: Sabina M Baumgartner-Parzer; Ferdinand Rudolf Waldenberger; Angelika Freudenthaler; Amandine Ginouvès-Guerdoux; David McGahie; Hugues Gatto Journal: ISRN Vet Sci Date: 2012-11-26