Literature DB >> 22151402

Intrathecal baclofen for the treatment of intractable spasticity of spine or brain etiology.

A M Avellino1, J D Loeser.   

Abstract

Objective. To determine the long-term relief of spasticity and complication rates in patients who underwent placement of a programmable intrathecal baclofen pump for treatment of medically intractable spasticity of spine or brain etiology. Methods. Sixty-two consecutive adult patients who underwent placement of a programmable pump were retrospectively reviewed. Results. Spasticity was clinically and statistically significantly decreased in all patients. Catheter-related kinks, breaks, dislodgments, and disconnections were the most common complications followed by drug-related effects, infections, and wound complications. Conclusions. Intrathecal baclofen is a very effective strategy for the relief of medically intractable spasticity of spine or brain etiology. Even though 36% of patients have required revisions, no patient has experienced any long-term morbidity. Patients and their primary care givers have been pleased with the long-term effects of this therapy upon quality of life.

Entities:  

Year:  2000        PMID: 22151402     DOI: 10.1046/j.1525-1403.2000.00075.x

Source DB:  PubMed          Journal:  Neuromodulation        ISSN: 1094-7159


  5 in total

Review 1.  [Continuous intrathecal administration of medication. Special features in anaesthesiology and intensive care].

Authors:  P Felleiter; P Lierz
Journal:  Anaesthesist       Date:  2007-08       Impact factor: 1.041

2.  Intrathecal Delivery of BDNF Into the Lumbar Cistern Re-Engages Locomotor Stepping After Spinal Cord Injury.

Authors:  Francesca Marchionne; Alexander J Krupka; George M Smith; Michel A Lemay
Journal:  IEEE Trans Neural Syst Rehabil Eng       Date:  2020-11-06       Impact factor: 3.802

3.  Treatment of severe, disabling spasticity with continuous intrathecal baclofen therapy following acquired brain injury: the experience of a tertiary institution in Singapore.

Authors:  Zhe Min Wang; Jia Hao Law; Nicolas Kon Kam King; Deshan Kumar Rajeswaran; Samantha Soh; Jai Prashanth Rao; Wai Hoe Ng; Karen Sui Geok Chua
Journal:  Singapore Med J       Date:  2016-01       Impact factor: 1.858

Review 4.  Role of Catheter's Position for Final Results in Intrathecal Drug Delivery. Analysis Based on CSF Dynamics and Specific Drugs Profiles.

Authors:  De Andres Jose; Perotti Luciano; Villanueva Vicente; Asensio Samper Juan Marcos; Fabregat-Cid Gustavo
Journal:  Korean J Pain       Date:  2013-10-02

Review 5.  Baclofen in the Therapeutic of Sequele of Traumatic Brain Injury: Spasticity.

Authors:  Adán Pérez-Arredondo; Eduardo Cázares-Ramírez; Paul Carrillo-Mora; Marina Martínez-Vargas; Noemí Cárdenas-Rodríguez; Elvia Coballase-Urrutia; Radamés Alemón-Medina; Aristides Sampieri; Luz Navarro; Liliana Carmona-Aparicio
Journal:  Clin Neuropharmacol       Date:  2016 Nov/Dec       Impact factor: 1.592

  5 in total

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