Literature DB >> 22150303

Ikaros and tumor suppression in acute lymphoblastic leukemia.

Kimberly J Payne1, Sinisa Dovat.   

Abstract

The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling. The biological roles of Ikaros include regulating the development and function of the immune system and acting as a master regulator of hematopoietic differentiation. Genomic profiling studies identified Ikzf1 as an important tumor suppressor in acute lymphoblastic leukemia (ALL), particularly in ALL that is associated with poor prognosis. This review summarizes currently available data regarding the structure and function of Ikaros, the clinical relevance of genetic inactivation of Ikzf1, and signal transduction pathways that regulate Ikaros function.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22150303      PMCID： PMC3243972          DOI： 10.1615/critrevoncog.v16.i1-2.20

Source DB:  PubMed          Journal:  Crit Rev Oncog        ISSN： 0893-9675


  64 in total

1.  A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains.

Authors:  Sinisa Dovat; Tapani Ronni; Dana Russell; Roger Ferrini; Bradley S Cobb; Stephen T Smale
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

Review 2.  Assembly of silent chromatin during thymocyte development.

Authors:  Ruey-Chyi Su; Rupa Sridharan; Stephen T Smale
Journal:  Semin Immunol       Date:  2005-04       Impact factor: 11.130

Review 3.  The role of the Ikaros gene in lymphocyte development and homeostasis.

Authors:  K Georgopoulos; S Winandy; N Avitahl
Journal:  Annu Rev Immunol       Date:  1997       Impact factor: 28.527

4.  IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

Authors:  R P Kuiper; E Waanders; V H J van der Velden; S V van Reijmersdal; R Venkatachalam; B Scheijen; E Sonneveld; J J M van Dongen; A J P Veerman; F N van Leeuwen; A Geurts van Kessel; P M Hoogerbrugge
Journal:  Leukemia       Date:  2010-05-06       Impact factor: 11.528

5.  Ikaros isoforms: The saga continues.

Authors:  Zhanjun Li; Laura A Perez-Casellas; Aleksandar Savic; Chunhua Song; Sinisa Dovat
Journal:  World J Biol Chem       Date:  2011-06-26

6.  The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene.

Authors:  K Hahm; P Ernst; K Lo; G S Kim; C Turck; S T Smale
Journal:  Mol Cell Biol       Date:  1994-11       Impact factor: 4.272

7.  Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms.

Authors:  Tapani Ronni; Kimberly J Payne; Sam Ho; Michelle N Bradley; Glenn Dorsam; Sinisa Dovat
Journal:  J Biol Chem       Date:  2006-11-29       Impact factor: 5.157

8.  Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

Authors:  Koichi Nakase; Fumihiko Ishimaru; Keiko Fujii; Takayuki Tabayashi; Teruhiko Kozuka; Nobuo Sezaki; Yoshinobu Matsuo; Mine Harada
Journal:  Exp Hematol       Date:  2002-04       Impact factor: 3.084

9.  Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.

Authors:  Richard C Harvey; Charles G Mullighan; I-Ming Chen; Walker Wharton; Fady M Mikhail; Andrew J Carroll; Huining Kang; Wei Liu; Kevin K Dobbin; Malcolm A Smith; William L Carroll; Meenakshi Devidas; W Paul Bowman; Bruce M Camitta; Gregory H Reaman; Stephen P Hunger; James R Downing; Cheryl L Willman
Journal:  Blood       Date:  2010-02-04       Impact factor: 22.113

10.  Submicroscopic deletions in 5q- associated malignancies.

Authors:  Barbara Crescenzi; Roberta La Starza; Silvia Romoli; Donatella Beacci; Caterina Matteucci; Gianluca Barba; Ana Aventin; Peter Marynen; Stefania Ciolli; Chiara Nozzoli; Massimo Fabrizio Martelli; Cristina Mecucci
Journal:  Haematologica       Date:  2004-03       Impact factor: 9.941
View more
  29 in total

Review 1.  Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.

Authors:  Chandrika Gowda; Mario Soliman; Malika Kapadia; Yali Ding; Kimberly Payne; Sinisa Dovat
Journal:  Adv Biol Regul       Date:  2017-06-13

2.  Revealing new therapeutic opportunities through drug target prediction: a class imbalance-tolerant machine learning approach.

Authors:  Siqi Liang; Haiyuan Yu
Journal:  Bioinformatics       Date:  2020-08-15       Impact factor: 6.937

3.  Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.

Authors:  Philip A Beer; David J H F Knapp; Paul H Miller; Nagarajan Kannan; Ivan Sloma; Kathy Heel; Sonja Babovic; Elizabeth Bulaeva; Gabrielle Rabu; Jefferson Terry; Brian J Druker; Marc M Loriaux; Keith R Loeb; Jerald P Radich; Wendy N Erber; Connie J Eaves
Journal:  Blood       Date:  2014-11-04       Impact factor: 22.113

Review 4.  Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros.

Authors:  Chandrika Gowda; Chunhua Song; Malika Kapadia; Jonathon L Payne; Tommy Hu; Yali Ding; Sinisa Dovat
Journal:  Adv Biol Regul       Date:  2016-09-18

5.  Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells.

Authors:  Tawin Iempridee; Jessica A Reusch; Andrew Riching; Eric C Johannsen; Sinisa Dovat; Shannon C Kenney; Janet E Mertz
Journal:  J Virol       Date:  2014-02-12       Impact factor: 5.103

6.  Ikaros6 is associated with BCR-ABL1 and myeloid-associated antigens but indicates poor prognosis independently in Chinese adult B-cell acute lymphoblastic leukemia.

Authors:  Na Zhang; Chunrui Li; Danmei Xu; Yanan Liu; Xiaoyi Ding; Kefeng Shen; Jianfeng Zhou; Min Xiao
Journal:  Int J Clin Exp Med       Date:  2015-06-15

7.  ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Authors:  Amy M Linabery; Crystal N Blommer; Logan G Spector; Stella M Davies; Leslie L Robison; Julie A Ross
Journal:  Leuk Res       Date:  2013-05-18       Impact factor: 3.156

8.  A proteome-scale map of the human interactome network.

Authors:  Thomas Rolland; Murat Taşan; Benoit Charloteaux; Samuel J Pevzner; Quan Zhong; Nidhi Sahni; Song Yi; Irma Lemmens; Celia Fontanillo; Roberto Mosca; Atanas Kamburov; Susan D Ghiassian; Xinping Yang; Lila Ghamsari; Dawit Balcha; Bridget E Begg; Pascal Braun; Marc Brehme; Martin P Broly; Anne-Ruxandra Carvunis; Dan Convery-Zupan; Roser Corominas; Jasmin Coulombe-Huntington; Elizabeth Dann; Matija Dreze; Amélie Dricot; Changyu Fan; Eric Franzosa; Fana Gebreab; Bryan J Gutierrez; Madeleine F Hardy; Mike Jin; Shuli Kang; Ruth Kiros; Guan Ning Lin; Katja Luck; Andrew MacWilliams; Jörg Menche; Ryan R Murray; Alexandre Palagi; Matthew M Poulin; Xavier Rambout; John Rasla; Patrick Reichert; Viviana Romero; Elien Ruyssinck; Julie M Sahalie; Annemarie Scholz; Akash A Shah; Amitabh Sharma; Yun Shen; Kerstin Spirohn; Stanley Tam; Alexander O Tejeda; Shelly A Trigg; Jean-Claude Twizere; Kerwin Vega; Jennifer Walsh; Michael E Cusick; Yu Xia; Albert-László Barabási; Lilia M Iakoucheva; Patrick Aloy; Javier De Las Rivas; Jan Tavernier; Michael A Calderwood; David E Hill; Tong Hao; Frederick P Roth; Marc Vidal
Journal:  Cell       Date:  2014-11-20       Impact factor: 41.582

Review 9.  Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review.

Authors:  Leena Rivina; Robert Schiestl
Journal:  Int J Environ Res Public Health       Date:  2012-12-27       Impact factor: 3.390

Review 10.  Germline IKZF1 mutations and their impact on immunity: IKAROS-associated diseases and pathophysiology.

Authors:  Hye Sun Kuehn; Cristiane J Nunes-Santos; Sergio D Rosenzweig
Journal:  Expert Rev Clin Immunol       Date:  2021-03-19       Impact factor: 4.473
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.