Literature DB >> 22149279

A mouse monoclonal antibody against the γ2 subunit of GABAA receptors.

Suchitra Joshi1, Chengsan Sun, Jaideep Kapur.   

Abstract

A mouse monoclonal antibody directed against the N terminal extracellular epitope of rat γ amino butyric acid (GABA) type-A (GABA(A)R) receptor γ2 subunit was generated. This antibody identified a protein of approximately 42 kDa in Western blot assays using rat and mouse hippocampal proteins. The antibody also detected the expression of γ2 subunit by immunohistochemistry and could immunoprecipitate the γ2 subunit.

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Year:  2011        PMID： 22149279      PMCID： PMC3278817          DOI： 10.1089/hyb.2011.0035

Source DB:  PubMed          Journal:  Hybridoma (Larchmt)        ISSN： 1554-0014


  20 in total

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Review 6.  Molecular biology of GABAA receptors.

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5.  The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration.

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