Literature DB >> 22148937

Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer.

Seiji Hayashi1, Yusuke Oji, Yuko Kanai, Tomoaki Teramoto, Masanori Kitaichi, Tomoya Kawaguchi, Masaji Okada, Haruo Sugiyama, Akihide Matsumura.   

Abstract

We elucidated the relationship between prognosis of non-small-cell lung cancer (NSCLC) and Wilms' tumor gene (WT1) mRNA expression in tumor tissue. The WT1 mRNA expression levels of the fatal cases were lower as compared with those of the survival cases. Overall survival (OS) and disease-free survival (DFS) of the high WT1 expression group were longer than of the low expression group. As for squamous cell lung cancer (SQLC), low WT1 expression was significantly associated with lymph node metastasis. Cox analysis revealed that the gene level was a significant prognostic factor in OS and DFS. Low WT1 expression predicted poor prognosis in patients with NSCLC.

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Year:  2011        PMID： 22148937     DOI： 10.3109/07357907.2011.633291

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  6 in total

1.  Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells.

Authors:  Heidge Fukumasu; Arina L Rochetti; Pedro R L Pires; Edson R Silva; Ligia G Mesquita; Ricardo F Strefezzi; Daniel D De Carvalho; Maria L Dagli
Journal:  PLoS One       Date:  2014-06-24       Impact factor: 3.240

Review 2.  Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.

Authors:  Xiao-wei Qi; Fan Zhang; Hong Wu; Jun-lan Liu; Bei-ge Zong; Chuan Xu; Jun Jiang
Journal:  Sci Rep       Date:  2015-03-09       Impact factor: 4.379

3.  Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers.

Authors:  Junjie Chen; Shenmeng Gao; Chunjing Wang; Zhonggai Wang; Huxiang Zhang; Kate Huang; Bin Zhou; Haiying Li; Zhijie Yu; Jianbo Wu; Chengshui Chen
Journal:  J Exp Clin Cancer Res       Date:  2016-11-07

Review 4.  WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease.

Authors:  Wen-Chin Lee; Chien-Hua Chiu; Tian-Huei Chu; Yu-Shu Chien
Journal:  Front Cell Dev Biol       Date:  2022-04-06

5.  Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

Authors:  Hiroaki Asai; Hiroshi Fujiwara; Jun An; Toshiki Ochi; Yukihiro Miyazaki; Kozo Nagai; Sachiko Okamoto; Junichi Mineno; Kiyotaka Kuzushima; Hiroshi Shiku; Hirofumi Inoue; Masaki Yasukawa
Journal:  PLoS One       Date:  2013-02-18       Impact factor: 3.240

6.  WT1 promotes cell proliferation in non-small cell lung cancer cell lines through up-regulating cyclin D1 and p-pRb in vitro and in vivo.

Authors:  Caihua Xu; Chen Wu; Yang Xia; Zhaopeng Zhong; Xiang Liu; Jing Xu; Fei Cui; Bin Chen; Oluf Dimitri Røe; Aihong Li; Yijiang Chen
Journal:  PLoS One       Date:  2013-08-01       Impact factor: 3.240
  6 in total

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