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Literature DB >> 22148076

A rare cause of hypoglycaemia.

Pinaki Dutta¹, Anil Bhansali, Santosh Kumar, P Jayaprakash, Uma Nahar.

Abstract

We describe the case of a 77-year-old man who was admitted with recurrent episodes of altered behaviour. These episodes were related to insulin-like growth factor II (IGF-II) mediated hypoglycaemia. Imaging revealed a large retroperitoneal mass and he underwent debulking surgery uneventfully. Histopathology revealed a solitary fibroma with intense immunostaining positive for CD34 and vimentin, suggesting a mesenchymal origin of the tumour. Later he received chemo/radiotherapy and is on prednisolone with abatement of hypoglycaemic episodes.

Entities: Chemical Disease Gene Species

Year: 2009 PMID： 22148076 PMCID： PMC3029287 DOI： 10.1136/bcr.04.2009.1789

Source DB: PubMed Journal: BMJ Case Rep ISSN： 1757-790X

13 in total

1. Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix.

Authors: M J Seckl; P J Mulholland; A E Bishop; J D Teale; C N Hales; M Glaser; S Watkins; J R Seckl
Journal: N Engl J Med Date: 1999-09-02 Impact factor: 91.245

2. The mechanism of non-islet cell hypoglycaemia caused by tumour-produced IGF-II.

Authors: S Zachariah; A Brackenridge; F Shojaee-Moradie; C Camuncho-Hubner; A M Umpleby; D Russell-Jones
Journal: Clin Endocrinol (Oxf) Date: 2007-06-20 Impact factor: 3.478

3. Mechanisms of tumor-induced hypoglycemia with intraabdominal hemangiopericytoma.

Authors: J Chung; R R Henry
Journal: J Clin Endocrinol Metab Date: 1996-03 Impact factor: 5.958

4. Gene expression and serum levels of insulin-like growth factors (IGFs) and IGF-binding proteins in a case of non-islet cell tumour hypoglycaemia.

Authors: R I Holt; J D Teale; J S Jones; J D Quin; A M McGregor; J P Miell
Journal: Growth Horm IGF Res Date: 1998-12 Impact factor: 2.372

Review 5. The role of insulin-like growth factors and their binding proteins in tumor hypoglycemia.

Authors: R C Baxter
Journal: Horm Res Date: 1996

6. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.

Authors: W H Daughaday; M A Emanuele; M H Brooks; A L Barbato; M Kapadia; P Rotwein
Journal: N Engl J Med Date: 1988-12-01 Impact factor: 91.245

7. Glucocorticoid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumours inducing hypoglycaemia (NICTH)

Authors: J D Teale; V Marks
Journal: Clin Endocrinol (Oxf) Date: 1998-10 Impact factor: 3.478

8. Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

Authors: J Zapf; E Futo; M Peter; E R Froesch
Journal: J Clin Invest Date: 1992-12 Impact factor: 14.808

A rare cause of hypoglycaemia.

1. Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix.

2. The mechanism of non-islet cell hypoglycaemia caused by tumour-produced IGF-II.

3. Mechanisms of tumor-induced hypoglycemia with intraabdominal hemangiopericytoma.

4. Gene expression and serum levels of insulin-like growth factors (IGFs) and IGF-binding proteins in a case of non-islet cell tumour hypoglycaemia.

Review 5. The role of insulin-like growth factors and their binding proteins in tumor hypoglycemia.

6. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia.

7. Glucocorticoid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumours inducing hypoglycaemia (NICTH)

8. Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?

Review 9. Hemangiopericytoma: histopathological pattern or clinicopathologic entity?

10. The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia.

1. Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature.

2. Non-Islet Cell Tumor Hypoglycemia: A Rare Cause of Hypoglycemia in Pulmonary Sarcomatoid Cancer.