Metal-free, organocatalytic cascade formation of C-N and C-O bonds through dual sp3 C-H activation: oxidative synthesis of oxazole derivatives.

An organocatalytic cascade reaction that involves the formation of C-N, C-O and C=N bonds in one process via dual sp(3) C-H activation has been developed. This protocol affords a facile metal-free methodology for the synthesis of oxazole derivatives in air under mild conditions. This journal is © The Royal Society of Chemistry 2012