| Literature DB >> 22146591 |
Ju Zhang1, Xiaomin Lou, Shangbin Yang, Shun He, Lei Yang, Mei Liu, Hongxia Zhu, Qiang Shan, Siyuan Su, Qimin Zhan, Ningzhi Xu, Siqi Liu.
Abstract
Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells. This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence. The association of the c-Myc/SP1 complex with the BAG2 promoter verified the role of c-Myc/SP1 in regulating BAG2 transcription. Furthermore, high levels of BAG2 were found to induce p21(CIP1)-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21(CIP1) pathway.Entities:
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Year: 2011 PMID： 22146591 DOI： 10.1016/j.canlet.2011.11.033
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679