BACKGROUND: Angioedema is an infrequent but potentially serious adverse effect of angiotensin converting enzyme inhibitors (ACEIs). OBJECTIVE: This article describes a case of ACEI associated angioedema and reviews important clinical features of the condition. DISCUSSION: The mechanism of ACEI associated angioedema is not allergic (histamine mediated), but rather due to an alteration of the balance of bradykinin and other vasodilator mediators. Onset may be delayed for weeks, months or years and episodes may be recurrent. Occasionally, airway obstruction may occur. Diagnosis is from history and physical examination; there is no specific diagnostic test. In contrast to allergic angioedema, ACEI associated angioedema is generally unresponsive to corticosteroids and antihistamines, although these agents are often used by convention. In the longer term, cessation of the ACEI is necessary to reduce the risk of recurrent episodes.
BACKGROUND:Angioedema is an infrequent but potentially serious adverse effect of angiotensin converting enzyme inhibitors (ACEIs). OBJECTIVE: This article describes a case of ACEI associated angioedema and reviews important clinical features of the condition. DISCUSSION: The mechanism of ACEI associated angioedema is not allergic (histamine mediated), but rather due to an alteration of the balance of bradykinin and other vasodilator mediators. Onset may be delayed for weeks, months or years and episodes may be recurrent. Occasionally, airway obstruction may occur. Diagnosis is from history and physical examination; there is no specific diagnostic test. In contrast to allergic angioedema, ACEI associated angioedema is generally unresponsive to corticosteroids and antihistamines, although these agents are often used by convention. In the longer term, cessation of the ACEI is necessary to reduce the risk of recurrent episodes.
Authors: M Wadelius; S E Marshall; G Islander; L Nordang; M Karawajczyk; Q-Y Yue; I Terreehorst; E V Baranova; S Hugosson; K Sköldefors; M Pirmohamed; A-H Maitland-van der Zee; A Alfirevic; P Hallberg; C N A Palmer Journal: Clin Pharmacol Ther Date: 2014-06-24 Impact factor: 6.875