| Literature DB >> 22144676 |
Neeta Patel1, Patarabutr Masaratana, Javier Diaz-Castro, Gladys O Latunde-Dada, Aakafa Qureshi, Pamela Lockyer, Molly Jacob, Matthew Arno, Pavle Matak, Ragai R Mitry, Robin D Hughes, Anil Dhawan, Cam Patterson, Robert J Simpson, Andrew T McKie.
Abstract
The BMP/SMAD4 pathway has major effects on liver hepcidin levels. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator (Bmper), a known regulator of BMP signaling, was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trf(hpx/hpx)). Soluble BMPER peptide inhibited BMP2- and BMP6-dependent hepcidin promoter activity in both HepG2 and HuH7 cells. These effects correlated with reduced cellular levels of pSMAD1/5/8. Addition of BMPER peptide to primary human hepatocytes abolished the BMP2-dependent increase in hepcidin mRNA, whereas injection of Bmper peptide into mice resulted in reduced liver hepcidin and increased serum iron levels. Thus Bmper may play an important role in suppressing hepcidin production in hypotransferrinemic mice.Entities:
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Year: 2011 PMID： 22144676 PMCID： PMC3281740 DOI： 10.1074/jbc.M111.310789
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157