Literature DB >> 22144272

Rho GTPases and cancer cell transendothelial migration.

Nicolas Reymond1, Philippe Riou, Anne J Ridley.   

Abstract

Small Rho GTPases are major regulators of actin cytoskeleton dynamics and influence cell shape and migration. The expression of several Rho GTPases is often up-regulated in tumors and this frequently correlates with a poor prognosis for patients. Migration of cancer cells through endothelial cells that line the blood vessels, called transendothelial migration or extravasation, is a critical step during the metastasis process. The use of siRNA technology to target specifically each Rho family member coupled with imaging techniques allows the roles of individual Rho GTPases to be investigated. In this chapter we describe methods to assess how Rho GTPases affect the different steps of cancer cell transendothelial cell migration in vitro.

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Year:  2012        PMID： 22144272     DOI： 10.1007/978-1-61779-442-1_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  15 in total

Review 1.  Viral activation of stress-regulated Rho-GTPase signaling pathway disrupts sites of mRNA degradation to influence cellular gene expression.

Authors:  Jennifer A Corcoran; Craig McCormick
Journal:  Small GTPases       Date:  2015-10-19

Review 2.  Crossing the endothelial barrier during metastasis.

Authors:  Nicolas Reymond; Bárbara Borda d'Água; Anne J Ridley
Journal:  Nat Rev Cancer       Date:  2013-12       Impact factor: 60.716

3.  Quantification of cancer cell extravasation in vivo.

Authors:  Yohan Kim; Karla C Williams; Carson T Gavin; Emily Jardine; Ann F Chambers; Hon S Leong
Journal:  Nat Protoc       Date:  2016-04-21       Impact factor: 13.491

4.  Towards embedding Caco-2 model of gut interface in a microfluidic device to enable multi-organ models for systems biology.

Authors:  Dmitry Sakharov; Diana Maltseva; Evgeny Knyazev; Sergey Nikulin; Andrey Poloznikov; Sergey Shilin; Ancha Baranova; Irina Tsypina; Alexander Tonevitsky
Journal:  BMC Syst Biol       Date:  2019-03-05

5.  Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion.

Authors:  Xiuping Zhou; Zhi Liu; Qiong Shi; Jiantong Jiao; Wenbin Bian; Xu Song; Jianbing Mo; Ben Sang; Yinfu Xu; Jinming Qian; Yuewen Chao; Rutong Yu
Journal:  J Neurooncol       Date:  2013-03-09       Impact factor: 4.130

Review 6.  Hyaluronan regulation of endothelial barrier function in cancer.

Authors:  Patrick A Singleton
Journal:  Adv Cancer Res       Date:  2014       Impact factor: 6.242

7.  Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits Gα13/RhoA-mediated Migration.

Authors:  Kisha A Scarlett; El-Shaddai Z White; Christopher J Coke; Jada R Carter; Latoya K Bryant; Cimona V Hinton
Journal:  Mol Cancer Res       Date:  2018-01-12       Impact factor: 5.852

8.  Cdc42 promotes transendothelial migration of cancer cells through β1 integrin.

Authors:  Nicolas Reymond; Jae Hong Im; Ritu Garg; Francisco M Vega; Barbara Borda d'Agua; Philippe Riou; Susan Cox; Ferran Valderrama; Ruth J Muschel; Anne J Ridley
Journal:  J Cell Biol       Date:  2012-11-12       Impact factor: 10.539

9.  Metastasis suppressor NME1 regulates melanoma cell morphology, self-adhesion and motility via induction of fibronectin expression.

Authors:  Marián Novak; Mary Kathryn Leonard; Xiuwei H Yang; Anjan Kowluru; Alexey M Belkin; David M Kaetzel
Journal:  Exp Dermatol       Date:  2015-04-27       Impact factor: 3.960

10.  Tumor Cell Mechanosensing During Incorporation into the Brain Microvascular Endothelium.

Authors:  Marina A Pranda; Kelsey M Gray; Ariana Joy L DeCastro; Gregory M Dawson; Jae W Jung; Kimberly M Stroka
Journal:  Cell Mol Bioeng       Date:  2019-08-28       Impact factor: 2.321
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