| Literature DB >> 22144269 |
Natalia Mitin1, Patrick J Roberts, Emily J Chenette, Channing J Der.
Abstract
The Rho family comprises a major branch of the Ras superfamily of small GTPases. A majority of Rho GTPases are synthesized as inactive, cytosolic proteins. They then undergo posttranslational modification by isoprenoid or fatty acid lipids, and together with additional carboxyl-terminal sequences target Rho GTPases to specific membrane and subcellular compartments essential for function. We summarize the use of biochemical and cellular assays and pharmacologic inhibitors instrumental for the study of the role of posttranslational lipid modifications and processing in Rho GTPase biology.Entities:
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Year: 2012 PMID： 22144269 DOI： 10.1007/978-1-61779-442-1_6
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745