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Literature DB >> 22143957

Malondialdehyde, Bcl-2, superoxide dismutase and glutathione peroxidase may mediate the association of sonic hedgehog protein and oxidative stress in autism.

Abstract

Sonic hedgehog signaling and brain-derived neurotrophic factor play a neuro-protective role against oxidative stress in autism. Sonic hedgehog also increases Bcl-2 expression and the activities of superoxide dismutase and glutathione peroxidase. The level or activity of Bcl-2, brain-derived neurotrophic factor, and the activities of superoxide dismutase and glutathione peroxidase are decreased in autism. Sonic hedgehog also decreases the production of malondialdehyde that its level is high in autism. Therefore, it is supposed that sonic hedgehog may be associated with oxidative stress in autism through other pathways too.

Entities: Chemical Disease Gene

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Year: 2011 PMID： 22143957 DOI： 10.1007/s11064-011-0667-z

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

21 in total

1. Oxidative stress may mediate association of stereotypy and immunity in autism, a novel explanation with clinical and research implications.

Authors: Ahmad Ghanizadeh
Journal: J Neuroimmunol Date: 2010-11-13 Impact factor: 3.478

2. Targeting cerebral Bcl-2 expression as a potential therapeutic target in autism: potential usefulness of human recombinant nerve growth factor.

Authors: Marianna Boso; Stefania Ucelli di Nemi; Francesco Barale; Enzo Emanuele
Journal: Med Hypotheses Date: 2006-08-02 Impact factor: 1.538

3. Nuclear factor kappa B may increase insight into the management of neuroinflammation and excitotoxicity in autism.

Authors: Ahmad Ghanizadeh
Journal: Expert Opin Ther Targets Date: 2011-05-10 Impact factor: 6.902

4. Gold implants and increased expression of metallothionein-I/II as a novel hypothesized therapeutic approach for autism.

Authors: Ahmad Ghanizadeh
Journal: Toxicology Date: 2011-02-16 Impact factor: 4.221

5. A novel hypothesized clinical implication of zonisamide for autism.

Authors: Ahmad Ghanizadeh
Journal: Ann Neurol Date: 2011-02 Impact factor: 10.422

6. Could fever and neuroinflammation play a role in the neurobiology of autism? A subject worthy of more research.

Authors: Ahmad Ghanizadeh
Journal: Int J Hyperthermia Date: 2011-10-03 Impact factor: 3.914

7. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain.

Authors: AnhThu Nguyen; Tibor A Rauch; Gerd P Pfeifer; Valerie W Hu
Journal: FASEB J Date: 2010-04-07 Impact factor: 5.191

8. Evaluation of oxidative stress in autism: defective antioxidant enzymes and increased lipid peroxidation.

Authors: Nagwa A Meguid; Ahmed A Dardir; Ehab R Abdel-Raouf; Adel Hashish
Journal: Biol Trace Elem Res Date: 2010-09-16 Impact factor: 3.738

9. Targeting neurotensin as a potential novel approach for the treatment of autism.

Authors: Ahmad Ghanizadeh
Journal: J Neuroinflammation Date: 2010-10-01 Impact factor: 8.322

10. Investigation of antioxidant enzymes in children with autistic disorder.

Authors: O Yorbik; A Sayal; C Akay; D I Akbiyik; T Sohmen
Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2002-11 Impact factor: 4.006

17 in total

1. Assessment of gender and age effects on serum and hair trace element levels in children with autism spectrum disorder.

Authors: Anatoly V Skalny; Natalia V Simashkova; Anastasia A Skalnaya; Tatiana P Klyushnik; Geir Bjørklund; Margarita G Skalnaya; Alexey A Tinkov
Journal: Metab Brain Dis Date: 2017-06-29 Impact factor: 3.584

Review 2. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder.

Authors: Ria Gupta; Sidharth Mehan; Swesha Chhabra; Aditi Giri; Kajal Sherawat
Journal: Neurotox Res Date: 2022-10-22 Impact factor: 3.978

3. Sonic hedgehog signaling regulates hypoxia/reoxygenation-induced H9C2 myocardial cell apoptosis.

Authors: Rui-Ying Zhang; Zeng-Yong Qiao; Hua-Jin Liu; Jiang-Wei Ma
Journal: Exp Ther Med Date: 2018-09-03 Impact factor: 2.447

4. Molecular Pathways within Autism Spectrum Disorder Endophenotypes.

Authors: Silvana Briuglia; Marco Calabrò; Anna Paola Capra; Sara Briguori; Maria Angela La Rosa; Concetta Crisafulli
Journal: J Mol Neurosci Date: 2021-01-25 Impact factor: 3.444

Review 5. Molecular Mechanisms of Aberrant Neuroplasticity in Autism Spectrum Disorders (Review).

Authors: A A Anashkina; E I Erlykina
Journal: Sovrem Tekhnologii Med Date: 2021-02-28

6. Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis.

Authors: Kuang-Yao Chen; Chien-Ju Cheng; Lian-Chen Wang
Journal: Biomed Res Int Date: 2015-04-16 Impact factor: 3.411

7. Cysteinyl leukotriene correlated with 8-isoprostane levels as predictive biomarkers for sensory dysfunction in autism.

Authors: Hanan Qasem; Laila Al-Ayadhi; Afaf El-Ansary
Journal: Lipids Health Dis Date: 2016-08-17 Impact factor: 3.876

8. Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production.

Authors: Ahmad Ghanizadeh
Journal: Med Gas Res Date: 2012-07-30

9. Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials.

Authors: Ahmad Ghanizadeh
Journal: Med Gas Res Date: 2012-05-11

Review 10. Potential crosstalk between sonic hedgehog-WNT signaling and neurovascular molecules: Implications for blood-brain barrier integrity in autism spectrum disorder.

Authors: Evelyne Gozal; Rekha Jagadapillai; Jun Cai; Gregory N Barnes
Journal: J Neurochem Date: 2021-08-06 Impact factor: 5.546