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Literature DB >> 22143634

OPRM1 and diagnosis-related posttraumatic stress disorder in binge-drinking patients living with HIV.

Nicole R Nugent¹, Michelle A Lally, Larry Brown, Valerie S Knopik, John E McGeary.

Abstract

Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.

Entities: Chemical Disease Gene Mutation Species

Mesh：

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Year: 2012 PMID： 22143634 PMCID： PMC3711210 DOI： 10.1007/s10461-011-0095-8

Source DB: PubMed Journal: AIDS Behav ISSN： 1090-7165

72 in total

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Journal: Pharmacogenomics Date: 2007-10 Impact factor: 2.533

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Journal: Alcohol Clin Exp Res Date: 2004-12 Impact factor: 3.455

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Authors: Lara A Ray; Kent E Hutchison
Journal: Arch Gen Psychiatry Date: 2007-09

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Journal: Virology Date: 2003-04-25 Impact factor: 3.616

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9. Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes.

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Journal: Alcohol Clin Exp Res Date: 2008-07 Impact factor: 3.455

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Authors: Steven A Safren; Beth S Gershuny; Ellen Hendriksen
Journal: AIDS Patient Care STDS Date: 2003-12 Impact factor: 5.078

11 in total

1. Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents.

Authors: Gregory Swann; Gayle R Byck; Danielle M Dick; Fazil Aliev; Shawn J Latendresse; Brien Riley; Darlene Kertes; Cuie Sun; Jessica E Salvatore; John Bolland; Brian Mustanski
Journal: J Affect Disord Date: 2014-03-27 Impact factor: 4.839

2. Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use.

Authors: Kathleen A Brown-Rice; Jamie L Scholl; Kelene A Fercho; Kami Pearson; Noah A Kallsen; Gareth E Davies; Erik A Ehli; Seth Olson; Amy Schweinle; Lee A Baugh; Gina L Forster
Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2017-09-20 Impact factor: 5.067

3. Mouse model of OPRM1 (A118G) polymorphism increases sociability and dominance and confers resilience to social defeat.

Authors: Lisa A Briand; Monica Hilario; Holly C Dow; Edward S Brodkin; Julie A Blendy; Olivier Berton
Journal: J Neurosci Date: 2015-02-25 Impact factor: 6.167

Review 4. Pharmacological secondary prevention of PTSD in youth: challenges and opportunities for advancement.

Authors: Matthew A Maccani; Douglas L Delahanty; Nicole R Nugent; Steven J Berkowitz
Journal: J Trauma Stress Date: 2012-10

5. Coping Expectancies, Not Enhancement Expectancies, Mediate Trauma Experience Effects on Problem Alcohol Use: A Prospective Study From Early Childhood to Adolescence.

Authors: Jennifer M Jester; Davia B Steinberg; Mary M Heitzeg; Robert A Zucker
Journal: J Stud Alcohol Drugs Date: 2015-09 Impact factor: 2.582

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Authors: Mallory E Bowers; Kerry J Ressler
Journal: Biol Psychiatry Date: 2015-06-15 Impact factor: 13.382

7. Diagnosis and Healing In Veterans Suspected of Suffering from Post-Traumatic Stress Disorder (PTSD) Using Reward Gene Testing and Reward Circuitry Natural Dopaminergic Activation.

Authors: Kenneth Blum; John Giordano; Marlene Oscar-Berman; Abdalla Bowirrat; Thomas Simpatico; Debmalya Barh
Journal: J Genet Syndr Gene Ther Date: 2012-05-31

8. Drinking motives among HIV primary care patients.

Authors: Jennifer C Elliott; Efrat Aharonovich; Ann O'Leary; Milton Wainberg; Deborah S Hasin
Journal: AIDS Behav Date: 2014-07

9. Drinking motives moderate daily relationships between PTSD symptoms and alcohol use.

Authors: Tracy L Simpson; Cynthia A Stappenbeck; Jane A Luterek; Keren Lehavot; Debra L Kaysen
Journal: J Abnorm Psychol Date: 2014-02

10. Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users.

Authors: Rohan H C Palmer; Nicole R Nugent; Leslie A Brick; Cinnamon L Bidwell; John E McGeary; Matthew C Keller; Valerie S Knopik
Journal: J Trauma Stress Date: 2016-05-23