Literature DB >> 22143581

hβ2R-Gαs complex: prediction versus crystal structure--how valuable are predictions based on molecular modeling studies?

Andrea Straßer1, Hans-Joachim Wittmann.   

Abstract

In 2010, we predicted two models for the hβ(2)R-Gα(s) complex by combining the technique of homology modeling with a potential energy surface scan, since a complete crystal structure of the hβ(2)R-Gα(s) complex was not available. The crystal structure of opsin co-crystallized with part of the C-terminus of Gα (3DQB) was used as a template to model the hβ(2)R, whereas the crystal structure of Gα (1AZT) was used as a template to model Gα(s). Utilizing a potential energy surface scan between hβ(2)R and Gα(s), a six-dimensional potential energy surface was obtained. Two significant minimum regions were located on this surface, and each was associated with a distinct hβ(2)R-Gα(s) complex, namely model I and model II [Straßer A, Wittmann H-J (2010) J Mol Model 16:1307-1318]. The crystal structure of the hβ(2)R-Gα(s)βγ complex has recently been published. Thus, the aim of the current study was, on the one hand, to compare our predicted structures with the true crystal structure, and on the other to discuss the question: how valuable are predictions based on molecular modeling studies?

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Year:  2011        PMID: 22143581     DOI: 10.1007/s00894-011-1305-z

Source DB:  PubMed          Journal:  J Mol Model        ISSN: 0948-5023            Impact factor:   1.810


  17 in total

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Journal:  J Mol Model       Date:  2010-01-30       Impact factor: 1.810

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Journal:  Nat Rev Mol Cell Biol       Date:  2008-01       Impact factor: 94.444

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Journal:  Science       Date:  2007-10-25       Impact factor: 47.728

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Journal:  J Biol Chem       Date:  1998-07-17       Impact factor: 5.157

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Authors:  Patrick Scheerer; Jung Hee Park; Peter W Hildebrand; Yong Ju Kim; Norbert Krauss; Hui-Woog Choe; Klaus Peter Hofmann; Oliver P Ernst
Journal:  Nature       Date:  2008-09-25       Impact factor: 49.962

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Authors:  Tony Warne; Maria J Serrano-Vega; Jillian G Baker; Rouslan Moukhametzianov; Patricia C Edwards; Richard Henderson; Andrew G W Leslie; Christopher G Tate; Gebhard F X Schertler
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Journal:  Science       Date:  2008-10-02       Impact factor: 47.728

10.  Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors:  Søren G F Rasmussen; Brian T DeVree; Yaozhong Zou; Andrew C Kruse; Ka Young Chung; Tong Sun Kobilka; Foon Sun Thian; Pil Seok Chae; Els Pardon; Diane Calinski; Jesper M Mathiesen; Syed T A Shah; Joseph A Lyons; Martin Caffrey; Samuel H Gellman; Jan Steyaert; Georgios Skiniotis; William I Weis; Roger K Sunahara; Brian K Kobilka
Journal:  Nature       Date:  2011-07-19       Impact factor: 49.962

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  1 in total

1.  Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer.

Authors:  Andrea Straßer; Hans-Joachim Wittmann
Journal:  J Mol Model       Date:  2013-08-08       Impact factor: 1.810

  1 in total

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