Literature DB >> 22143568

Signal control through Raf: in sickness and in health.

Jihan K Osborne1, Elma Zaganjor, Melanie H Cobb.   

Abstract

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

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Year:  2011        PMID： 22143568      PMCID： PMC3351917          DOI： 10.1038/cr.2011.193

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  93 in total

1.  ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

Authors:  Michael C Lawrence; Kathleen McGlynn; Byung-Hyun Park; Melanie H Cobb
Journal:  J Biol Chem       Date:  2005-05-16       Impact factor: 5.157

2.  Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

Authors:  Angelina Rodriguez; Angeles Durán; Mohammed Selloum; Marie-France Champy; Francisco J Diez-Guerra; Juana María Flores; Manuel Serrano; Johan Auwerx; María T Diaz-Meco; Jorge Moscat
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

3.  Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

Authors:  Mathew J Garnett; Sareena Rana; Hugh Paterson; David Barford; Richard Marais
Journal:  Mol Cell       Date:  2005-12-22       Impact factor: 17.970

4.  Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells.

Authors:  Simone Kiermayer; Ricardo M Biondi; Jochen Imig; Guido Plotz; Jörg Haupenthal; Stefan Zeuzem; Albrecht Piiper
Journal:  Mol Biol Cell       Date:  2005-10-05       Impact factor: 4.138

5.  Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation.

Authors:  Sara C Shalin; Caterina M Hernandez; Michele K Dougherty; Deborah K Morrison; J David Sweatt
Journal:  Neuron       Date:  2006-06-01       Impact factor: 17.173

6.  In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.

Authors:  Nicolas Dumaz; Robert Hayward; Jan Martin; Lesley Ogilvie; Douglas Hedley; John A Curtin; Boris C Bastian; Caroline Springer; Richard Marais
Journal:  Cancer Res       Date:  2006-10-01       Impact factor: 12.701

7.  Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.

Authors:  Jeremy J Heit; Asa A Apelqvist; Xueying Gu; Monte M Winslow; Joel R Neilson; Gerald R Crabtree; Seung K Kim
Journal:  Nature       Date:  2006-09-21       Impact factor: 49.962

8.  The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis.

Authors:  Frédéric Bost; Myriam Aouadi; Leslie Caron; Patrick Even; Nathalie Belmonte; Matthieu Prot; Christian Dani; Paul Hofman; Gilles Pagès; Jacques Pouysségur; Yannick Le Marchand-Brustel; Bernard Binétruy
Journal:  Diabetes       Date:  2005-02       Impact factor: 9.461

9.  Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF.

Authors:  Victoria Emuss; Mathew Garnett; Clive Mason; Richard Marais
Journal:  Cancer Res       Date:  2005-11-01       Impact factor: 12.701

10.  Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.

Authors:  Gray W Pearson; Svetlana Earnest; Melanie H Cobb
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272
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  23 in total

1.  Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.

Authors:  Andrew C Emery; Maribeth V Eiden; Tomris Mustafa; Lee E Eiden
Journal:  Sci Signal       Date:  2013-06-25       Impact factor: 8.192

2.  MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development.

Authors:  Dinesh Upadhya; Masato Ogata; Lixing W Reneker
Journal:  Development       Date:  2013-04       Impact factor: 6.868

3.  Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

Authors:  David Romano; Lan K Nguyen; David Matallanas; Melinda Halasz; Carolanne Doherty; Boris N Kholodenko; Walter Kolch
Journal:  Nat Cell Biol       Date:  2014-06-15       Impact factor: 28.824

4.  The lack of Raf-1 kinase feedback regulation enhances antiapoptosis in cancer cells.

Authors:  S Q Ma; B R Cao; H Zhang; L P Luo; Y Ren; T Hu; C M Chen
Journal:  Oncogene       Date:  2016-11-14       Impact factor: 9.867

5.  The nuclear translocation of ERK1/2 as an anticancer target.

Authors:  Alexander Plotnikov; Karen Flores; Galia Maik-Rachline; Eldar Zehorai; Einat Kapri-Pardes; Denise A Berti; Tamar Hanoch; Michal J Besser; Rony Seger
Journal:  Nat Commun       Date:  2015-03-30       Impact factor: 14.919

6.  In vivo profiling reveals immunomodulatory effects of sorafenib and dacarbazine on melanoma.

Authors:  Mirjana Urosevic-Maiwald; Marjam J Barysch; Phil F Cheng; Maria B Karpova; Hans Steinert; Michal J Okoniewski; Reinhard Dummer
Journal:  Oncoimmunology       Date:  2015-01-07       Impact factor: 8.110

Review 7.  Ral GTPases in tumorigenesis: emerging from the shadows.

Authors:  David F Kashatus
Journal:  Exp Cell Res       Date:  2013-07-02       Impact factor: 3.905

8.  Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation.

Authors:  Maureen O Ripple; Namjoon Kim; Roger Springett
Journal:  J Biol Chem       Date:  2012-12-12       Impact factor: 5.157

9.  RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.

Authors:  Jessica J Mezzanotte; Victoria Hill; M Lee Schmidt; Thoraia Shinawi; Stella Tommasi; Dietmar Krex; Gabriele Schackert; Gerd P Pfeifer; Farida Latif; Geoffrey J Clark
Journal:  Epigenetics       Date:  2014-11       Impact factor: 4.528

10.  Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Authors:  Che-Hung Shen; Ping Yuan; Rolando Perez-Lorenzo; Yaqing Zhang; Sze Xian Lee; Yang Ou; John M Asara; Lewis C Cantley; Bin Zheng
Journal:  Mol Cell       Date:  2013-10-03       Impact factor: 17.970
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