Literature DB >> 22143053

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes.

Faustine Dubar1, Sylvain Bohic, Christian Slomianny, Jean-Charles Morin, Patrick Thomas, Hadidjatou Kalamou, Yann Guérardel, Peter Cloetens, Jamal Khalife, Christophe Biot.   

Abstract

We report here for the first time the in vitro localization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22143053     DOI： 10.1039/c1cc16211j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes.

Authors:  Faustine Dubar; Sylvain Bohic; Daniel Dive; Yann Guérardel; Peter Cloetens; Jamal Khalife; Christophe Biot
Journal:  ACS Med Chem Lett       Date:  2012-04-13       Impact factor: 4.345

2.  Antiprotozoal activity of ferroquine.

Authors:  S Pomel; C Biot; C Bories; P M Loiseau
Journal:  Parasitol Res       Date:  2012-11-15       Impact factor: 2.289

3.  Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.

Authors:  Carlos Sanchez-Cano; Isolda Romero-Canelón; Yang Yang; Ian J Hands-Portman; Sylvain Bohic; Peter Cloetens; Peter J Sadler
Journal:  Chemistry       Date:  2017-01-26       Impact factor: 5.236

4.  Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites.

Authors:  Nicolli Bellotti de Souza; Anna Caroline Campos Aguiar; Alane Cabral de Oliveira; Siden Top; Pascal Pigeon; Gérard Jaouen; Marilia Oliveira Fonseca Goulart; Antoniana Ursine Krettli
Journal:  Mem Inst Oswaldo Cruz       Date:  2015-11-24       Impact factor: 2.743

5.  Lensless Tomographic Imaging of Near Surface Structures of Frozen Hydrated Malaria-Infected Human Erythrocytes by Coherent X-Ray Diffraction Microscopy.

Authors:  Viktoria Frank; Yuriy Chushkin; Benjamin Fröhlich; Wasim Abuillan; Harden Rieger; Alexandra S Becker; Akihisa Yamamoto; Fernanda F Rossetti; Stefan Kaufmann; Michael Lanzer; Federico Zontone; Motomu Tanaka
Journal:  Sci Rep       Date:  2017-10-26       Impact factor: 4.379

6.  The antimalarial ferroquine is an inhibitor of hepatitis C virus.

Authors:  Thibaut Vausselin; Noémie Calland; Sandrine Belouzard; Véronique Descamps; Florian Douam; François Helle; Catherine François; Dimitri Lavillette; Gilles Duverlie; Ahmed Wahid; Lucie Fénéant; Laurence Cocquerel; Yann Guérardel; Czeslaw Wychowski; Christophe Biot; Jean Dubuisson
Journal:  Hepatology       Date:  2013-05-14       Impact factor: 17.425

Review 7.  Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.

Authors:  Timothy J Egan; David Kuter
Journal:  Future Microbiol       Date:  2013-04       Impact factor: 3.165

8.  Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo.

Authors:  Sergey Kapishnikov; Trine Staalsø; Yang Yang; Jiwoong Lee; Ana J Pérez-Berná; Eva Pereiro; Yang Yang; Stephan Werner; Peter Guttmann; Leslie Leiserowitz; Jens Als-Nielsen
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-28       Impact factor: 11.205

Review 9.  Malaria Pigment Crystals: The Achilles' Heel of the Malaria Parasite.

Authors:  Sergey Kapishnikov; Ernst Hempelmann; Michael Elbaum; Jens Als-Nielsen; Leslie Leiserowitz
Journal:  ChemMedChem       Date:  2021-03-19       Impact factor: 3.466
  9 in total

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