Literature DB >> 22142758

Effects of levodopa on forward and backward gait patterns in persons with Parkinson's disease.

M S Bryant1, D H Rintala, J G Hou, E C Lai, E J Protas.   

Abstract

INTRODUCTION: Backward walking is difficult for persons with Parkinson's disease (PD). It is unknown how levodopa influences backward gait patterns, especially when compared to forward gait patterns.
PURPOSE: Investigate the effects of levodopa on forward and backward gait patterns in individuals with PD.
DESIGN: A repeated measures design was used.
METHODS: The sample consisted of 21 individuals with PD (15 males, 6 females). Their mean age was 70.24 ± 8.69 yr. The average time since diagnosis was 11.81 ± 5.49 years. The median of the Hoehn and Yahr stage while 'ON' medication was 2.57. Gait patterns during forward and backward walking at a self-selected comfortable speed were recorded before and after taking levodopa on the same day.
RESULTS: Levodopa significantly increased gait speed and stride length and decreased the percent of the gait cycle (%GC) spent in double support. Gait speed and stride length were greater and the %GC spent in double support was less during forward walking compared with backward walking. Cadence was not changed by levodopa or walking direction.
CONCLUSIONS: Levodopa improved gait characteristics during backward walking in a manner similar to that during forward walking in persons with PD.

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Year:  2011        PMID: 22142758      PMCID: PMC3391536          DOI: 10.3233/NRE-2011-0700

Source DB:  PubMed          Journal:  NeuroRehabilitation        ISSN: 1053-8135            Impact factor:   2.138


  18 in total

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3.  Parkinsonism: onset, progression and mortality.

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4.  [Gait analysis in Parkinson's disease and response to dopaminergic treatment].

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5.  The validity of the GaitRite and the Functional Ambulation Performance scoring system in the analysis of Parkinson gait.

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6.  Basic gait parameters: reference data for normal subjects, 10-79 years of age.

Authors:  T Oberg; A Karsznia; K Oberg
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8.  Locomotor response to levodopa in fluctuating Parkinson's disease.

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10.  The pathogenesis of gait hypokinesia in Parkinson's disease.

Authors:  M E Morris; R Iansek; T A Matyas; J J Summers
Journal:  Brain       Date:  1994-10       Impact factor: 13.501

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  17 in total

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Review 7.  Effect of rhythmic auditory cueing on parkinsonian gait: A systematic review and meta-analysis.

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Journal:  Front Neurosci       Date:  2017-05-26       Impact factor: 4.677

Review 9.  The Impact of Exercise Intervention with Rhythmic Auditory Stimulation to Improve Gait and Mobility in Parkinson Disease: An Umbrella Review.

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10.  Predicting Falls in Parkinson Disease: What Is the Value of Instrumented Testing in OFF Medication State?

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