OBJECTIVES: To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes. METHODS: We selected all person with diabetes (N = 252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected. Collected variables included demographic characteristics, underlying medical conditions, outcome, clinical course and treatment. RESULTS: Among those suffering diabetes only 15.9% did not report any other underlying condition. 38% of diabetic patients and 27.4% of non diabetic patients were admitted to ICU (p = 0.008). Thirty subjects suffering diabetes and fifteen without the disease died (11.9% vs. 6%[p = 0.019]). Multivariable analysis showed that the independent risk factors for ICU admission or death were suffering cardiovascular disease (OR = 2.28), morbid obesity (OR = 2.08) and antiviral treatment started after 48 h of onset of symptoms (OR = 1.89). Suffering diabetes was not independent risk factors for ICU admission or death after adjusting for covariates. CONCLUSIONS: The worse outcome among diabetes sufferers could be a consequence of the higher prevalence of comorbid underlying medical conditions but not diabetes itself. Further prospective studies are needed to verify these results.
OBJECTIVES: To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes. METHODS: We selected all person with diabetes (N = 252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected. Collected variables included demographic characteristics, underlying medical conditions, outcome, clinical course and treatment. RESULTS: Among those suffering diabetes only 15.9% did not report any other underlying condition. 38% of diabeticpatients and 27.4% of non diabeticpatients were admitted to ICU (p = 0.008). Thirty subjects suffering diabetes and fifteen without the disease died (11.9% vs. 6%[p = 0.019]). Multivariable analysis showed that the independent risk factors for ICU admission or death were suffering cardiovascular disease (OR = 2.28), morbid obesity (OR = 2.08) and antiviral treatment started after 48 h of onset of symptoms (OR = 1.89). Suffering diabetes was not independent risk factors for ICU admission or death after adjusting for covariates. CONCLUSIONS: The worse outcome among diabetes sufferers could be a consequence of the higher prevalence of comorbid underlying medical conditions but not diabetes itself. Further prospective studies are needed to verify these results.
Authors: Gerardo Chowell; Santiago Echevarría-Zuno; Cécile Viboud; Lone Simonsen; Mark A Miller; Irma Fernández-Gárate; Cesar González-Bonilla; Víctor H Borja-Aburto Journal: PLoS One Date: 2012-07-16 Impact factor: 3.240
Authors: Kathryn A Radigan; Luisa Morales-Nebreda; Saul Soberanes; Trevor Nicholson; Recep Nigdelioglu; Takugo Cho; Monica Chi; Robert B Hamanaka; Alexander V Misharin; Harris Perlman; G R Scott Budinger; Gökhan M Mutlu Journal: PLoS One Date: 2014-09-18 Impact factor: 3.240
Authors: Rodrigo Jiménez-García; Valentín Hernández-Barrera; Cristina Rodríguez-Rieiro; Ana Lopez de Andres; Javier de Miguel-Diez; Isabel Jimenez-Trujillo; Angel Gil de Miguel; Pilar Carrasco-Garrido Journal: Influenza Other Respir Viruses Date: 2012-08-07 Impact factor: 4.380