Literature DB >> 22137788

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.

Young-Min Han1, Su-Kyung Lee, Dae Gwin Jeong, Seong Eon Ryu, Dong Cho Han, Dae Keun Kim, Byoung-Mog Kwon.   

Abstract

Anthraquinones have been reported as phosphatase inhibitors. Therefore, anthraquinone derivatives were screened to identify a potent phosphatase inhibitor against the phosphatase of regenerating liver-3 (PRL-3). Emodin strongly inhibited phosphatase activity of PRL-3 with IC(50) values of 3.5μM and blocked PRL-3-induced tumor cell migration and invasion in a dose-dependent manner. Emodin rescued the phosphorylation of ezrin, which is a known PRL-3 substrate. The results of this study reveal that emodin is a PRL-3 inhibitor and a good lead molecule for obtaining a selective PRL-3 inhibitor.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22137788     DOI： 10.1016/j.bmcl.2011.11.008

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1.

Authors:  Wei Qu; Yufei Wang; Qining Wu; Jijun Liu; Dingjun Hao
Journal:  Int J Clin Exp Med       Date:  2015-09-15

Review 2.  The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers.

Authors:  Qing Zhang; Wen Wen Chen; Xue Sun; Die Qian; Dan Dan Tang; Li Lin Zhang; Mei Yan Li; Lin Yu Wang; Chun-Jie Wu; Wei Peng
Journal:  Int J Biol Sci       Date:  2022-05-16       Impact factor: 10.750

Review 3.  Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.

Authors:  Michihiro Kobayashi; Sisi Chen; Rui Gao; Yunpeng Bai; Zhong-Yin Zhang; Yan Liu
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 4.  Phosphatase of regenerating liver: a novel target for cancer therapy.

Authors:  Amanda M Campbell; Zhong-Yin Zhang
Journal:  Expert Opin Ther Targets       Date:  2014-03-01       Impact factor: 6.902

5.  Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.

Authors:  Bharat Aggarwal; Sahdeo Prasad; Bokyung Sung; Sunil Krishnan; Sushovan Guha
Journal:  Curr Colorectal Cancer Rep       Date:  2013-03-01

6.  Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells.

Authors:  Chenyu Mao; Hao Liu; Ping Chen; Jingjia Ye; Lisong Teng; Zhenyu Jia; Jiang Cao
Journal:  Oncotarget       Date:  2015-03-20

7.  Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro.

Authors:  Jie-yu Xing; Gao-peng Song; Jun-peng Deng; Ling-zhi Jiang; Ping Xiong; Bin-jie Yang; Shan-shan Liu
Journal:  PLoS One       Date:  2015-12-18       Impact factor: 3.240

8.  Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-α and IL-6 Release by Blockading NF-κB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187.

Authors:  Yue Lu; Yong-Tae Jeong; Xian Li; Mi Jin Kim; Pil-Hoon Park; Seung-Lark Hwang; Jong Keun Son; Hyeun Wook Chang
Journal:  Biomol Ther (Seoul)       Date:  2013-11       Impact factor: 4.634

9.  Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.

Authors:  Birgit Hoeger; Maren Diether; Pedro J Ballester; Maja Köhn
Journal:  Eur J Med Chem       Date:  2014-08-20       Impact factor: 6.514

10.  Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer.

Authors:  Sigve Andersen; Elin Richardsen; Mehrdad Rakaee; Helena Bertilsson; Roy Bremnes; Magne Børset; Lill-Tove Busund; Tobias Slørdahl
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240
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