OBJECTIVE: To explore associations between measures of obstructive sleep apnea (OSA) and sleep quality, anthropometrics, and neurocognitive functioning in severely obese adolescents. STUDY DESIGN: This was a cross-sectional pilot study performed at an academic medical center in 37 severely obese (body mass index [BMI] >97th percentile) adolescents. Study evaluations included polysomnography, BMI, waist circumference, and standardized neurocognitive tests to assess memory, executive functioning, psychomotor efficiency, academic achievement, and an approximation of full-scale IQ. Outcome data were evaluated categorically, based on clinical criteria for the diagnosis of OSA, and continuously to quantify associations between sleep parameters, anthropometrics, and neurocognitive test results. RESULTS: Sleep fragmentation and poorer sleep quality were associated with reduced psychomotor efficiency, poorer memory recall, and lower scores on standardized academic tests. Having evidence of OSA was associated with lower math scores, but not with other neurocognitive measures. BMI and waist circumference were negatively associated with oxygen saturation. CONCLUSION: Our pilot study findings suggest that sleep fragmentation and poorer sleep quality have implications for neurocognitive functioning in obese adolescents. The epidemic of childhood obesity has dire implications, not only for increasing cardiometabolic pathology, but also for possibly promoting less readily apparent neurologic alterations associated with poor sleep quality.
OBJECTIVE: To explore associations between measures of obstructive sleep apnea (OSA) and sleep quality, anthropometrics, and neurocognitive functioning in severely obese adolescents. STUDY DESIGN: This was a cross-sectional pilot study performed at an academic medical center in 37 severely obese (body mass index [BMI] >97th percentile) adolescents. Study evaluations included polysomnography, BMI, waist circumference, and standardized neurocognitive tests to assess memory, executive functioning, psychomotor efficiency, academic achievement, and an approximation of full-scale IQ. Outcome data were evaluated categorically, based on clinical criteria for the diagnosis of OSA, and continuously to quantify associations between sleep parameters, anthropometrics, and neurocognitive test results. RESULTS: Sleep fragmentation and poorer sleep quality were associated with reduced psychomotor efficiency, poorer memory recall, and lower scores on standardized academic tests. Having evidence of OSA was associated with lower math scores, but not with other neurocognitive measures. BMI and waist circumference were negatively associated with oxygen saturation. CONCLUSION: Our pilot study findings suggest that sleep fragmentation and poorer sleep quality have implications for neurocognitive functioning in obese adolescents. The epidemic of childhood obesity has dire implications, not only for increasing cardiometabolic pathology, but also for possibly promoting less readily apparent neurologic alterations associated with poor sleep quality.
Authors: Michael S Urschitz; Anke Guenther; Esther Eggebrecht; Judith Wolff; Pilar M Urschitz-Duprat; Martin Schlaud; Christian F Poets Journal: Am J Respir Crit Care Med Date: 2003-05-28 Impact factor: 21.405
Authors: Stuart F Quan; Ron Wright; Carol M Baldwin; Kristine L Kaemingk; James L Goodwin; Tracy F Kuo; Alfred Kaszniak; Lori L Boland; Elise Caccappolo; Richard R Bootzin Journal: Sleep Med Date: 2006-07-03 Impact factor: 3.492
Authors: Daniel J Gottlieb; Cynthia Chase; Richard M Vezina; Timothy C Heeren; Michael J Corwin; Sanford H Auerbach; Debra E Weese-Mayer; Samuel M Lesko Journal: J Pediatr Date: 2004-10 Impact factor: 4.406
Authors: Christine M Swanson; Steven A Shea; Katie L Stone; Jane A Cauley; Clifford J Rosen; Susan Redline; Gerard Karsenty; Eric S Orwoll Journal: J Bone Miner Res Date: 2015-02 Impact factor: 6.741
Authors: Melissa S Xanthopoulos; Paul R Gallagher; Robert I Berkowitz; Jerilynn Radcliffe; Ruth Bradford; Carole L Marcus Journal: Sleep Date: 2015-03-01 Impact factor: 5.849
Authors: Tanya G Weinstock; Carol L Rosen; Carole L Marcus; Susan Garetz; Ron B Mitchell; Raouf Amin; Shalini Paruthi; Eliot Katz; Raanan Arens; Jia Weng; Kristie Ross; Ronald D Chervin; Susan Ellenberg; Rui Wang; Susan Redline Journal: Sleep Date: 2014-02-01 Impact factor: 5.849
Authors: Melinda E Chen; Aaditya G Chandramouli; Robert V Considine; Tamara S Hannon; Kieren J Mather Journal: Diabetes Care Date: 2017-11-28 Impact factor: 19.112
Authors: Wibke Kiunke; Christina Brandl; Ekaterini Georgiadou; Kerstin Gruner-Labitzke; Thomas Horbach; Hinrich Köhler; Martina de Zwaan; Astrid Müller Journal: Front Psychiatry Date: 2013-08-13 Impact factor: 4.157
Authors: Hebah A Salawi; Kathryn A Ambler; Rajdeep S Padwal; Diana R Mager; Catherine B Chan; Geoff D C Ball Journal: BMC Pediatr Date: 2014-06-19 Impact factor: 2.125