Literature DB >> 22137643

CXCL12: a new player in coronary disease identified through human genetics.

Samira S Farouk1, Daniel J Rader, Muredach P Reilly, Nehal N Mehta.   

Abstract

Genome-wide association studies (GWAS) of more than 100,000 people have revealed novel loci associated with coronary artery disease and myocardial infarction that present exciting opportunities to discover novel disease pathways. One such recently identified locus is on chromosome 10q11, near the gene for the chemokine CXCL12, which has been implicated in cardiovascular disease in both mouse and human studies. These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 22137643      PMCID： PMC3235407          DOI： 10.1016/j.tcm.2011.08.002

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  51 in total

1.  Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity.

Authors:  Maria De La Luz Sierra; Fuquan Yang; Masashi Narazaki; Ombretta Salvucci; David Davis; Robert Yarchoan; Hongwei H Zhang; Henry Fales; Giovanna Tosato
Journal:  Blood       Date:  2003-10-02       Impact factor: 22.113

2.  Crucial role of stromal cell-derived factor-1alpha in neointima formation after vascular injury in apolipoprotein E-deficient mice.

Authors:  Andreas Schober; Sandra Knarren; Michael Lietz; Elisa A Lin; Christian Weber
Journal:  Circulation       Date:  2003-10-27       Impact factor: 29.690

3.  Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.

Authors:  Jun-ichi Yamaguchi; Kengo Fukushima Kusano; Osamu Masuo; Atsuhiko Kawamoto; Marcy Silver; Satoshi Murasawa; Marta Bosch-Marce; Haruchika Masuda; Douglas W Losordo; Jeffrey M Isner; Takayuki Asahara
Journal:  Circulation       Date:  2003-03-11       Impact factor: 29.690

Review 4.  Coronary plaque disruption.

Authors:  E Falk; P K Shah; V Fuster
Journal:  Circulation       Date:  1995-08-01       Impact factor: 29.690

Review 5.  The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels.

Authors:  Nehal N Mehta; Mingyao Li; Dilusha William; Amit V Khera; Stephanie DerOhannessian; Liming Qu; Jane F Ferguson; Catherine McLaughlin; Lalarukh Haris Shaikh; Rhia Shah; Parth N Patel; Jonathan P Bradfield; Jing He; Ioannis M Stylianou; Hakon Hakonarson; Daniel J Rader; Muredach P Reilly
Journal:  Eur Heart J       Date:  2011-03-17       Impact factor: 29.983

6.  Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C.

Authors:  J F Wang; I W Park; J E Groopman
Journal:  Blood       Date:  2000-04-15       Impact factor: 22.113

Review 7.  Chemokines in the pathogenesis of vascular disease.

Authors:  Israel F Charo; Mark B Taubman
Journal:  Circ Res       Date:  2004-10-29       Impact factor: 17.367

Review 8.  Of mice and not men: differences between mouse and human immunology.

Authors:  Javier Mestas; Christopher C W Hughes
Journal:  J Immunol       Date:  2004-03-01       Impact factor: 5.422

9.  Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects.

Authors:  Jan K Damås; Torgun Waehre; Arne Yndestad; Thor Ueland; Fredrik Müller; Hans Geir Eiken; Are M Holm; Bente Halvorsen; Stig S Frøland; Lars Gullestad; Pål Aukrust
Journal:  Circulation       Date:  2002-07-02       Impact factor: 29.690

10.  Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

Authors:  T Nagasawa; H Kikutani; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205
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  25 in total

Review 1.  The enigma of genetics etiology of atherosclerosis in the post-GWAS era.

Authors:  A J Marian
Journal:  Curr Atheroscler Rep       Date:  2012-08       Impact factor: 5.113

Review 2.  Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions.

Authors:  Mark D DeBoer
Journal:  Nutrition       Date:  2012-09-28       Impact factor: 4.008

3.  Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines.

Authors:  Shuji Mizumoto; Duriya Fongmoon; Kazuyuki Sugahara
Journal:  Glycoconj J       Date:  2012-12-29       Impact factor: 2.916

4.  Macrophage-Specific IGF-1 Overexpression Reduces CXCL12 Chemokine Levels and Suppresses Atherosclerotic Burden in Apoe-Deficient Mice.

Authors:  Patricia Snarski; Sergiy Sukhanov; Tadashi Yoshida; Yusuke Higashi; Svitlana Danchuk; Bysani Chandrasekar; Di Tian; Vikara Rivera-Lopez; Patrick Delafontaine
Journal:  Arterioscler Thromb Vasc Biol       Date:  2021-12-02       Impact factor: 8.311

5.  LPS response pattern of inflammatory adipokines in an in vitro 3T3-L1 murine adipocyte model.

Authors:  Salvatore Chirumbolo; Guido Franceschetti; Elena Zoico; Clara Bambace; Luciano Cominacini; Mauro Zamboni
Journal:  Inflamm Res       Date:  2014-02-14       Impact factor: 4.575

6.  CXCL12 promotes atherosclerosis by downregulating ABCA1 expression via the CXCR4/GSK3β/β-cateninT120/TCF21 pathway.

Authors:  Jia-Hui Gao; Lin-Hao He; Xiao-Hua Yu; Zhen-Wang Zhao; Gang Wang; Jin Zou; Feng-Jiao Wen; Li Zhou; Xiang-Jun Wan; Da-Wei Zhang; Chao-Ke Tang
Journal:  J Lipid Res       Date:  2019-10-29       Impact factor: 5.922

7.  Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy.

Authors:  Santhosh Kumar Ghadge; Moritz Messner; Herbert Seiringer; Thomas Maurer; Simon Staggl; Tanja Zeller; Christian Müller; Daniela Börnigen; Wolfgang J Weninger; Stefan H Geyer; Sieghart Sopper; Anne Krogsdam; Gerhard Pölzl; Axel Bauer; Marc-Michael Zaruba
Journal:  Int J Mol Sci       Date:  2021-05-31       Impact factor: 5.923

8.  Polydatin Reduces Cardiotoxicity and Enhances the Anticancer Effects of Sunitinib by Decreasing Pro-Oxidative Stress, Pro-Inflammatory Cytokines, and NLRP3 Inflammasome Expression.

Authors:  Vincenzo Quagliariello; Massimiliano Berretta; Simona Buccolo; Martina Iovine; Andrea Paccone; Ernesta Cavalcanti; Rosaria Taibi; Monica Montopoli; Gerardo Botti; Nicola Maurea
Journal:  Front Oncol       Date:  2021-06-11       Impact factor: 6.244

Review 9.  MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities.

Authors:  Emiel P C van der Vorst; Yvonne Döring; Christian Weber
Journal:  Front Immunol       Date:  2015-07-21       Impact factor: 7.561

10.  The hematopoietic chemokine CXCL12 promotes integration of human endothelial colony forming cell-derived cells into immature vessel networks.

Authors:  Sarah E Newey; Grigorios Tsaknakis; Cheen P Khoo; Thanassi Athanassopoulos; Rosalba Camicia; Youyi Zhang; Rita Grabowska; Adrian L Harris; Maria G Roubelakis; Suzanne M Watt
Journal:  Stem Cells Dev       Date:  2014-07-25       Impact factor: 3.272
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