Mai Sakaguchi1, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki. 1. Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, Japan.
Abstract
STUDY OBJECTIVE: To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. DESIGN: Single-center, prospective, randomized clinical trial. SETTING:Academic outpatient clinic. SUBJECTS:40 ASA physical status 1 and 2 patients with intellectual disability. INTERVENTIONS: Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. MEASUREMENTS: The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. MAIN RESULTS: BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. CONCLUSION:Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
RCT Entities:
STUDY OBJECTIVE: To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. DESIGN: Single-center, prospective, randomized clinical trial. SETTING: Academic outpatient clinic. SUBJECTS: 40 ASA physical status 1 and 2 patients with intellectual disability. INTERVENTIONS:Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. MEASUREMENTS: The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. MAIN RESULTS:BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. CONCLUSION:Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
Authors: Seung In Seo; Ji Yon Ryu; Sang Soo Kang; Jin Seo Lee; Hyoung Su Kim; Myoung Kuk Jang; Hak Yang Kim; Woon Geon Shin Journal: Dig Dis Sci Date: 2016-08-01 Impact factor: 3.199