Mahzad Alimian1, Masood Mohseni. 1. Department of Anesthesiology, Rasul Akram Hospital, Tehran University of Medical Science, Tehran, Iran. Alimian.mahzad@gmail.com
Abstract
STUDY OBJECTIVES: To evaluate the effects of intravenous (IV) tranexamic acid on blood loss and surgical field quality during functional endoscopic sinus surgery (FESS). DESIGN: Randomized, double-blinded, controlled trial. SETTING: Operating room and postoperative recovery area of a university-affiliated hospital. PATIENTS: 84 consecutive, adult, ASA physical status 1 and 2 patients undergoing FESS. INTERVENTIONS: Patients were randomized to receive either IV tranexamic acid 10 mg/kg (TA group) or sterile water 0.1 mL/kg (placebo group) as a bolus dose immediately after induction of anesthesia. MEASUREMENTS: Amount of blood loss and bleeding and satisfaction scores were obtained from the surgeon. MAIN RESULTS:Blood loss in the TA group was 184 ± 64 mL and in the placebogroup, 312 ± 75 mL on average (P < 0.01). The median (range) bleeding score in the TA group was significantly lower than the placebo group [2 (1-3) vs 2.5 (2-4); P < 0.0001]. The surgeon was more satisfied with the surgical field in the TA group than the placebo group [median score: 4 (3-5) vs 3 (1-5), P < 0.001]. CONCLUSION:Intravenous tranexamic acid effectively reduces bleeding and improves the surgical field during FESS.
RCT Entities:
STUDY OBJECTIVES: To evaluate the effects of intravenous (IV) tranexamic acid on blood loss and surgical field quality during functional endoscopic sinus surgery (FESS). DESIGN: Randomized, double-blinded, controlled trial. SETTING: Operating room and postoperative recovery area of a university-affiliated hospital. PATIENTS: 84 consecutive, adult, ASA physical status 1 and 2 patients undergoing FESS. INTERVENTIONS:Patients were randomized to receive either IV tranexamic acid 10 mg/kg (TA group) or sterile water 0.1 mL/kg (placebo group) as a bolus dose immediately after induction of anesthesia. MEASUREMENTS: Amount of blood loss and bleeding and satisfaction scores were obtained from the surgeon. MAIN RESULTS:Blood loss in the TA group was 184 ± 64 mL and in the placebo group, 312 ± 75 mL on average (P < 0.01). The median (range) bleeding score in the TA group was significantly lower than the placebo group [2 (1-3) vs 2.5 (2-4); P < 0.0001]. The surgeon was more satisfied with the surgical field in the TA group than the placebo group [median score: 4 (3-5) vs 3 (1-5), P < 0.001]. CONCLUSION: Intravenous tranexamic acid effectively reduces bleeding and improves the surgical field during FESS.
Authors: Vijendra S Shenoy; Nidhin Prakash; Panduranga M Kamath; Raghavendra A Rao; D Deviprasad; Vishnu Prasad; Vikranth Kamboj; Lavan Kumar Borra Journal: Indian J Otolaryngol Head Neck Surg Date: 2017-10-10