OBJECTIVE: We hypothesize that airflow limitation is associated with increasing arterial stiffness and that having COPD increases a non-invasive measure of arterial stiffness - the aortic augmentation index (AIx) - independently of other CVD risk factors. METHODS: This population study is based on 3374 subjects from the Copenhagen City Heart Study; 494 had COPD. We used multiple linear regression analyses to examine the association between COPD and AIx adjusted for CVD risk factors. Furthermore, we analyzed the association between AIx and FEV(1), FVC and FEV(1)/FVC in the entire population. RESULTS: AIx was higher in subjects with COPD than in subjects without: 25.7 vs. 21.0 (p < 0.001) in men and 33.6 vs. 29.4 (p < 0.001) in women. We found no increase in AIx with COPD adjusted for CVD risk factors: difference 0.63 (-0.26 to 1.52, p = 0.16). In sensitivity analyses in subjects younger than 60 years with exclusion of mild COPD from the analyses, COPD was associated with an increase in AIx in men only of 4.1 (0.88-7.22, p = 0.007). AIx had a curvilinear association with FEV(1) and FVC but no association with the FEV(1)/FVC ratio. CONCLUSION: AIx and COPD are only weakly associated. In the general population, this finding argues against increased arterial stiffness, as measured by AIx, being a complication of COPD.
OBJECTIVE: We hypothesize that airflow limitation is associated with increasing arterial stiffness and that having COPD increases a non-invasive measure of arterial stiffness - the aortic augmentation index (AIx) - independently of other CVD risk factors. METHODS: This population study is based on 3374 subjects from the Copenhagen City Heart Study; 494 had COPD. We used multiple linear regression analyses to examine the association between COPD and AIx adjusted for CVD risk factors. Furthermore, we analyzed the association between AIx and FEV(1), FVC and FEV(1)/FVC in the entire population. RESULTS: AIx was higher in subjects with COPD than in subjects without: 25.7 vs. 21.0 (p < 0.001) in men and 33.6 vs. 29.4 (p < 0.001) in women. We found no increase in AIx with COPD adjusted for CVD risk factors: difference 0.63 (-0.26 to 1.52, p = 0.16). In sensitivity analyses in subjects younger than 60 years with exclusion of mild COPD from the analyses, COPD was associated with an increase in AIx in men only of 4.1 (0.88-7.22, p = 0.007). AIx had a curvilinear association with FEV(1) and FVC but no association with the FEV(1)/FVC ratio. CONCLUSION: AIx and COPD are only weakly associated. In the general population, this finding argues against increased arterial stiffness, as measured by AIx, being a complication of COPD.
Authors: A Ç Aykan; T Gökdeniz; F Boyacı; I Gül; E Hatem; E Kalaycıoğlu; T Turan; H Bektaş; M B Cilingir; D A Aykan; F Ayyıldız; S Altun Journal: Herz Date: 2013-08-03 Impact factor: 1.443
Authors: Marie Fisk; Carmel M McEniery; Nichola Gale; Kaisa Mäki-Petäjä; Julia R Forman; Margaret Munnery; Jean Woodcock-Smith; Joseph Cheriyan; Divya Mohan; Jonathan Fuld; Ruth Tal-Singer; Michael I Polkey; John R Cockcroft; Ian B Wilkinson Journal: Hypertension Date: 2018-01-22 Impact factor: 10.190
Authors: Jing Pan; Lin Xu; Tai Hing Lam; Chao Qiang Jiang; Wei Sen Zhang; Feng Zhu; Ya Li Jin; G Neil Thomas; Kar Keung Cheng; Peymane Adab Journal: BMC Pulm Med Date: 2018-05-21 Impact factor: 3.317
Authors: Surya P Bhatt; Hrudaya P Nath; Young-Il Kim; Rekha Ramachandran; Jubal R Watts; Nina L J Terry; Sushil Sonavane; Swati P Deshmane; Prescott G Woodruff; Elizabeth C Oelsner; Sandeep Bodduluri; MeiLan K Han; Wassim W Labaki; J Michael Wells; Fernando J Martinez; R Graham Barr; Mark T Dransfield Journal: Respir Res Date: 2018-12-18
Authors: Linnea Qvist; Ulf Nilsson; Viktor Johansson; Kjell Larsson; Eva Rönmark; Jeremy Langrish; Anders Blomberg; Anne Lindberg Journal: Eur Clin Respir J Date: 2015-03-16