BACKGROUND AND AIMS: Variants in the transcription factor 7-like 2 (TCF7L2) gene are consistently associated with type 2 diabetes in adults, but the association of TCF7L2 with weight-related traits and body fat in humans is unclear. The aim of this study was to determine the relationship between the TCF7L2 gene (rs12255372) and obese phenotype in Mexican school-age children. METHODS: The study was performed in schools in Mexico City; 186 obese and 194 control children were studied. Fasting insulin and glucose, total cholesterol, LDL-C, HDL-C and triglycerides concentration were determined. The variant rs12255372 of the TCF7L2 gene was genotyped. We used age- and sex-adjusted linear models to test for association with metabolic measurements with this variant. RESULTS: Genotype of the TCF7L2 rs12255372 gene was associated with lower fasting plasma glucose (p = 0.001) and lower homeostasis model assessment of insulin resistance (HOMA-R; p = 0.001) in nonobese children. Heterozygous carriers for this variant were more prevalent in lean children (32.5%) than in the obese group (23.7%), which resulted in a strong protective effect for the normal weight condition (OR = 0.56, 0.32-0.97). CONCLUSIONS: TCF7L2 rs12255372 polymorphism protects Mexican children from obesity. Further research in other large, population-based studies is needed to replicate these findings.
BACKGROUND AND AIMS: Variants in the transcription factor 7-like 2 (TCF7L2) gene are consistently associated with type 2 diabetes in adults, but the association of TCF7L2 with weight-related traits and body fat in humans is unclear. The aim of this study was to determine the relationship between the TCF7L2 gene (rs12255372) and obese phenotype in Mexican school-age children. METHODS: The study was performed in schools in Mexico City; 186 obese and 194 control children were studied. Fasting insulin and glucose, total cholesterol, LDL-C, HDL-C and triglycerides concentration were determined. The variant rs12255372 of the TCF7L2 gene was genotyped. We used age- and sex-adjusted linear models to test for association with metabolic measurements with this variant. RESULTS: Genotype of the TCF7L2rs12255372 gene was associated with lower fasting plasma glucose (p = 0.001) and lower homeostasis model assessment of insulin resistance (HOMA-R; p = 0.001) in nonobese children. Heterozygous carriers for this variant were more prevalent in lean children (32.5%) than in the obese group (23.7%), which resulted in a strong protective effect for the normal weight condition (OR = 0.56, 0.32-0.97). CONCLUSIONS:TCF7L2rs12255372 polymorphism protects Mexican children from obesity. Further research in other large, population-based studies is needed to replicate these findings.
Authors: Jenny Vilchis-Gil; Marcia Galván-Portillo; Miguel Klünder-Klünder; Miguel Cruz; Samuel Flores-Huerta Journal: BMC Public Health Date: 2015-02-11 Impact factor: 3.295
Authors: Elvis Ndonwi Ngwa; Eugene Sobngwi; Barbara Atogho-Tiedeu; Jean Jacques N Noubiap; Olivier Sontsa Donfack; Magellan Guewo-Fokeng; Edith Pascale Mato Mofo; Priscille Pokam Fosso; Eric Djahmeni; Rosine Djokam-Dadjeu; Marie-Solange Evehe; Folefac Aminkeng; Wilfred F Mbacham; Jean Claude Mbanya Journal: BMC Res Notes Date: 2015-11-25