| Literature DB >> 22136905 |
C Bhupendra Reddy1, K Suresh Kumar, M Anil Kumar, M Veera Narayana Reddy, B Satheesh Krishna, M Naveen, M K Arunasree, C Suresh Reddy, C Naga Raju, C Devendranath Reddy.
Abstract
One pot three-component PEG-SO(3)H catalyzed reaction of 4-(Pyridin-4-yl)benzaldehyde and triethyl phosphite with various primary amines afforded α-aminophosphonates with high yields by the Kabachnik-Field's reaction. These new structurally diversified set of α-aminophosphonates (4a-j) were evaluated for their anti-tumor activity on human chronic myeloid leukemia cells (K 562), human colon carcinoma cells (Colo 205) along with non-cancerous human embryonic kidney cells (HEK 293). They showed moderate activity on both cancerous cells and non-cancerous cells.Entities:
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Year: 2011 PMID： 22136905 DOI： 10.1016/j.ejmech.2011.11.026
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514