| Literature DB >> 22136739 |
S E Smith1, E V Kurbatova, J S Cavanaugh, J P Cegielski.
Abstract
Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.Entities:
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Year: 2012 PMID: 22136739 PMCID: PMC4593497 DOI: 10.5588/ijtld.11.0445
Source DB: PubMed Journal: Int J Tuberc Lung Dis ISSN: 1027-3719 Impact factor: 2.373