Literature DB >> 22135354

An integrated biochemistry and genetics outreach program designed for elementary school students.

Eric D Ross1, Sarah K Lee, Catherine A Radebaugh, Laurie A Stargell.   

Abstract

Exposure to genetic and biochemical experiments typically occurs late in one's academic career. By the time students have the opportunity to select specialized courses in these areas, many have already developed negative attitudes toward the sciences. Given little or no direct experience with the fields of genetics and biochemistry, it is likely that many young people rule these out as potential areas of study or career path. To address this problem, we developed a 7-week (~1 hr/week) hands-on course to introduce fifth grade students to basic concepts in genetics and biochemistry. These young students performed a series of investigations (ranging from examining phenotypic variation, in vitro enzymatic assays, and yeast genetic experiments) to explore scientific reasoning through direct experimentation. Despite the challenging material, the vast majority of students successfully completed each experiment, and most students reported that the experience increased their interest in science. Additionally, the experiments within the 7-week program are easily performed by instructors with basic skills in biological sciences. As such, this program can be implemented by others motivated to achieve a broader impact by increasing the accessibility of their university and communicating to a young audience a positive impression of the sciences and the potential for science as a career.

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Year:  2011        PMID: 22135354      PMCID: PMC3276649          DOI: 10.1534/genetics.111.135285

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  18 in total

1.  'How many female scientists do you know?'.

Authors:  Robert A Jones
Journal:  Endeavour       Date:  2005-06       Impact factor: 0.444

2.  Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis.

Authors:  Shu-Xing Li; Yong-Ping Tong; Xiao-Cong Xie; Qi-Hai Wang; Hui-Na Zhou; Yi Han; Zhan-Yu Zhang; Wei Gao; Sheng-Guang Li; Xuejun C Zhang; Ru-Chang Bi
Journal:  J Mol Biol       Date:  2006-12-16       Impact factor: 5.469

3.  Note on an exact treatment of contingency, goodness of fit and other problems of significance.

Authors:  G H FREEMAN; J H HALTON
Journal:  Biometrika       Date:  1951-06       Impact factor: 2.445

4.  The media: the image of the scientist is bad.

Authors:  T H Maugh
Journal:  Science       Date:  1978-04-07       Impact factor: 47.728

5.  Probing the role of aromatic residues at the secondary saccharide-binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding.

Authors:  Chandran Ragunath; Suba G A Manuel; Venkat Venkataraman; Hameetha B R Sait; Chinnasamy Kasinathan; Narayanan Ramasubbu
Journal:  J Mol Biol       Date:  2008-10-14       Impact factor: 5.469

6.  Diet and the evolution of human amylase gene copy number variation.

Authors:  George H Perry; Nathaniel J Dominy; Katrina G Claw; Arthur S Lee; Heike Fiegler; Richard Redon; John Werner; Fernando A Villanea; Joanna L Mountain; Rajeev Misra; Nigel P Carter; Charles Lee; Anne C Stone
Journal:  Nat Genet       Date:  2007-09-09       Impact factor: 38.330

Review 7.  Molecular genetics of human lactase deficiencies.

Authors:  Irma Järvelä; Suvi Torniainen; Kaija-Leena Kolho
Journal:  Ann Med       Date:  2009       Impact factor: 4.709

8.  Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity.

Authors:  Narayanan Ramasubbu; Chandran Ragunath; Prasunkumar J Mishra; Leonard M Thomas; Gyöngyi Gyémánt; Lili Kandra
Journal:  Eur J Biochem       Date:  2004-06

9.  Red pigment of adenine-deficient yeast Saccharomyces cerevisiae.

Authors:  M N Smirnov; V N Smirnov; E I Budowsky; S G Inge-Vechtomov; N G Serebrjakov
Journal:  Biochem Biophys Res Commun       Date:  1967-05-05       Impact factor: 3.575

10.  In praise of model organisms.

Authors:  Gregory A Petsko
Journal:  Genome Biol       Date:  2011-05-30       Impact factor: 13.583

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