Literature DB >> 2213506

Interferon-alpha treatment leads to accumulation of virus particles on the surface of cells persistently infected with the human immunodeficiency virus type 1.

Y Yasuda1, S Miyake, S Kato, M Kita, T Kishida, T Kimura, K Ikuta.   

Abstract

The effect of interferon-alpha (IFN-alpha) on virus replication in cells acutely infected with human immunodeficiency virus type 1 (HIV-1) and virus production from cells persistently infected with HIV-1 was studied. In both cell systems, significant suppression was observed. However, this suppression was not due to protein synthesis of the major viral proteins. Electron microscopy revealed the accumulation of intact virus particles on the cell surface of the cells treated with IFN-alpha. Thus, IFN-alpha might suppress the release stage of the particle from infected cells.

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Year:  1990        PMID： 2213506

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr (1988)        ISSN： 0894-9255


  10 in total

1.  Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.

Authors:  Atsushi Okumura; Gengshi Lu; Ian Pitha-Rowe; Paula M Pitha
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-24       Impact factor: 11.205

2.  Alpha interferon suppresses virion but not soluble human immunodeficiency virus antigen production in chronically infected T-lymphocytic cells.

Authors:  B F Fernie; G Poli; A S Fauci
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

Review 3.  Insights into cellular factors that regulate HIV-1 replication in human cells.

Authors:  Andrew M L Lever; Kuan-Teh Jeang
Journal:  Biochemistry       Date:  2011-01-24       Impact factor: 3.162

4.  Evidence for a different susceptibility of primate lentiviruses to type I interferons.

Authors:  Stéphanie Cordeil; Xuan-Nhi Nguyen; Gregory Berger; Stéphanie Durand; Michelle Ainouze; Andrea Cimarelli
Journal:  J Virol       Date:  2012-12-19       Impact factor: 5.103

Review 5.  Antiviral activity of the interferon-induced cellular protein BST-2/tetherin.

Authors:  Andrey Tokarev; Mark Skasko; Kathleen Fitzpatrick; John Guatelli
Journal:  AIDS Res Hum Retroviruses       Date:  2009-12       Impact factor: 2.205

6.  Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120.

Authors:  B D Hansen; P L Nara; R K Maheshwari; G S Sidhu; J G Bernbaum; D Hoekzema; M S Meltzer; H E Gendelman
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

Review 7.  Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.

Authors:  A Roulston; R Lin; P Beauparlant; M A Wainberg; J Hiscott
Journal:  Microbiol Rev       Date:  1995-09

8.  Phenotypic properties of transmitted founder HIV-1.

Authors:  Nicholas F Parrish; Feng Gao; Hui Li; Elena E Giorgi; Hannah J Barbian; Erica H Parrish; Lara Zajic; Shilpa S Iyer; Julie M Decker; Amit Kumar; Bhavna Hora; Anna Berg; Fangping Cai; Jennifer Hopper; Thomas N Denny; Haitao Ding; Christina Ochsenbauer; John C Kappes; Rachel P Galimidi; Anthony P West; Pamela J Bjorkman; Craig B Wilen; Robert W Doms; Meagan O'Brien; Nina Bhardwaj; Persephone Borrow; Barton F Haynes; Mark Muldoon; James P Theiler; Bette Korber; George M Shaw; Beatrice H Hahn
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-29       Impact factor: 11.205

Review 9.  Host factors influencing susceptibility to HIV infection and AIDS progression.

Authors:  Juan Lama; Vicente Planelles
Journal:  Retrovirology       Date:  2007-07-25       Impact factor: 4.602

10.  The interferon response inhibits HIV particle production by induction of TRIM22.

Authors:  Stephen D Barr; James R Smiley; Frederic D Bushman
Journal:  PLoS Pathog       Date:  2008-02-29       Impact factor: 6.823
  10 in total

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