Literature DB >> 22134725

Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.

Gang Chen1, Jing Yang, Suo Gao, Hongping He, Shunlin Li, Yingtong Di, Ying Chang, Yang Lu, Xiaojiang Hao.   

Abstract

A series of spiro-oxindole derivatives was synthesized by novel regioselective 1,3-dipolar cycloadditions of isatin, α-amino acids, and (E)-β-aryl-nitro-olefins. Regioisomers were produced in each reaction and the major products showed different regioselectivity compared to previously reported spiro-oxindole derivatives.

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Year:  2011        PMID: 22134725     DOI: 10.1007/s11030-011-9342-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN: 1381-1991            Impact factor:   2.943


  3 in total

1.  Enantio- and diastereoselective Michael reaction of 1,3-dicarbonyl compounds to nitroolefins catalyzed by a bifunctional thiourea.

Authors:  Tomotaka Okino; Yasutaka Hoashi; Tomihiro Furukawa; Xuenong Xu; Yoshiji Takemoto
Journal:  J Am Chem Soc       Date:  2005-01-12       Impact factor: 15.419

2.  NaNO2-mediated transformation of aliphatic secondary nitroalkanes into ketones or oximes under neutral, aqueous conditions: how the nitro derivative catalyzes its own transformation.

Authors:  Arnaud Gissot; Silvere N'Gouela; Christophe Matt; Alain Wagner; Charles Mioskowski
Journal:  J Org Chem       Date:  2004-12-24       Impact factor: 4.354

3.  Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines.

Authors:  A Amal Raj; R Raghunathan; M R SrideviKumari; N Raman
Journal:  Bioorg Med Chem       Date:  2003-02-06       Impact factor: 3.641

  3 in total
  2 in total

Review 1.  Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis-Beirut Reaction.

Authors:  Juergen Ramharter; Michael Kulhanek; Maike Dettling; Gerhard Gmaschitz; Jale Karolyi-Oezguer; Harald Weinstabl; Andreas Gollner
Journal:  Org Process Res Dev       Date:  2022-07-07       Impact factor: 3.858

2.  New bactericide derived from Isatin for treating oilfield reinjection water.

Authors:  Gang Chen; Hui-Jun Su; Min Zhang; Fang Huo; Jie Zhang; Xiao-Jiang Hao; Jing-Rui Zhao
Journal:  Chem Cent J       Date:  2012-08-28       Impact factor: 4.215

  2 in total

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