INTRODUCTION: Information is limited regarding health-related quality of life (QOL) status of long-term (greater than 5 years) lung cancer survivors (LTLCS). Obtaining knowledge about their QOL changes over time is a critical step toward improving poor and maintaining good QOL. The primary aim of this study was to conduct a 7-year longitudinal study in survivors of primary lung cancer which identified factors associated with either decline or improvement in QOL over time. METHODS: Between 1997 and 2003, 447 LTLCS were identified and followed through 2007 using validated questionnaires; data on overall QOL and specific symptoms were at two periods: short-term (less than 3 years) and long-term postdiagnosis. The main analyses were of clinically significant changes (greater than 10%) and factors associated with overall QOL and symptom burden for each period and for changes over time. RESULTS: Three hundred two (68%) underwent surgical resection only and 122 (27%) received surgical resection and radiation/chemotherapy. Recurrent or new lung malignancies were observed in 84 (19%) survivors. Significant decline or improvement in overall QOL over time were reported in 155 (35%) and 67 (15%) of 447 survivors, respectively. Among the 155 whose QOL declined, significantly worsened symptoms were fatigue (69%), pain (59%), dyspnea (58%), depressed appetite (49%), and coughing (42%). The symptom burden did not lessen among the 67 who reported improvement in overall QOL, suggesting that survivors had adapted to their compromised physical condition. CONCLUSIONS: LTLCS suffered substantial symptom burden that significantly impaired their QOL, indicating a need for targeted interventions to alleviate their symptoms.
INTRODUCTION: Information is limited regarding health-related quality of life (QOL) status of long-term (greater than 5 years) lung cancer survivors (LTLCS). Obtaining knowledge about their QOL changes over time is a critical step toward improving poor and maintaining good QOL. The primary aim of this study was to conduct a 7-year longitudinal study in survivors of primary lung cancer which identified factors associated with either decline or improvement in QOL over time. METHODS: Between 1997 and 2003, 447 LTLCS were identified and followed through 2007 using validated questionnaires; data on overall QOL and specific symptoms were at two periods: short-term (less than 3 years) and long-term postdiagnosis. The main analyses were of clinically significant changes (greater than 10%) and factors associated with overall QOL and symptom burden for each period and for changes over time. RESULTS: Three hundred two (68%) underwent surgical resection only and 122 (27%) received surgical resection and radiation/chemotherapy. Recurrent or new lung malignancies were observed in 84 (19%) survivors. Significant decline or improvement in overall QOL over time were reported in 155 (35%) and 67 (15%) of 447 survivors, respectively. Among the 155 whose QOL declined, significantly worsened symptoms were fatigue (69%), pain (59%), dyspnea (58%), depressed appetite (49%), and coughing (42%). The symptom burden did not lessen among the 67 who reported improvement in overall QOL, suggesting that survivors had adapted to their compromised physical condition. CONCLUSIONS: LTLCS suffered substantial symptom burden that significantly impaired their QOL, indicating a need for targeted interventions to alleviate their symptoms.
Authors: Patricia A Ganz; Katherine A Desmond; Beth Leedham; Julia H Rowland; Beth E Meyerowitz; Thomas R Belin Journal: J Natl Cancer Inst Date: 2002-01-02 Impact factor: 13.506
Authors: Andrea L Cheville; Paul J Novotny; Jeffrey A Sloan; Jeffrey R Basford; Jason A Wampfler; Yolanda I Garces; Aminah Jatoi; Ping Yang Journal: J Pain Symptom Manage Date: 2011-03-12 Impact factor: 3.612
Authors: Antonio L Visbal; Brent A Williams; Francis C Nichols; Randolph S Marks; James R Jett; Marie-Christine Aubry; Eric S Edell; Jason A Wampfler; Julian R Molina; Ping Yang Journal: Ann Thorac Surg Date: 2004-07 Impact factor: 4.330
Authors: Adam Svobodník; Ping Yang; Paul J Novotny; Eric Bass; Yolanda I Garces; James R Jett; James A Bonner; Jeff A Sloan Journal: Mayo Clin Proc Date: 2004-08 Impact factor: 7.616
Authors: Sonia A Duffy; Jeffrey E Terrell; Marcia Valenstein; David L Ronis; Laurel A Copeland; Mary Connors Journal: Gen Hosp Psychiatry Date: 2002 May-Jun Impact factor: 3.238
Authors: I-Chan Huang; Tara M Brinkman; Kelly Kenzik; James G Gurney; Kirsten K Ness; Jennifer Lanctot; Elizabeth Shenkman; Leslie L Robison; Melissa M Hudson; Kevin R Krull Journal: J Clin Oncol Date: 2013-10-14 Impact factor: 44.544
Authors: Donald R Sullivan; Karen B Eden; Nathan F Dieckmann; Sara E Golden; Kelly C Vranas; Shannon M Nugent; Christopher G Slatore Journal: Lung Cancer Date: 2019-03-09 Impact factor: 5.705
Authors: Nora K Horick; Ariela Muzikansky; Hilda L Gutierrez; Kristina L Boyd; Dianne M Finkelstein Journal: J Cancer Surviv Date: 2018-10-12 Impact factor: 4.442
Authors: Amy J Hoffman; Ruth Ann Brintnall; Barbara A Given; Alexander von Eye; Lee W Jones; Jean K Brown Journal: Cancer Nurs Date: 2017 Jan/Feb Impact factor: 2.592