Literature DB >> 22133881

Pancreatic ductal cells in development, regeneration, and neoplasia.

Maximilian Reichert1, Anil K Rustgi.   

Abstract

The pancreas is a complex organ comprised of three critical cell lineages: islet (endocrine), acinar, and ductal. This review will focus upon recent insights and advances in the biology of pancreatic ductal cells. In particular, emphasis will be placed upon the regulation of ductal cells by specific transcriptional factors during development as well as the underpinnings of acinar-ductal metaplasia as an important adaptive response during injury and regeneration. We also address the potential contributions of ductal cells to neoplastic transformation, specifically in pancreatic ductal adenocarcinoma.

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Year:  2011        PMID： 22133881      PMCID： PMC3225990          DOI： 10.1172/JCI57131

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  101 in total

1.  Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.

Authors:  Takeshi Miyatsuka; Hideaki Kaneto; Toshihiko Shiraiwa; Taka-aki Matsuoka; Kaoru Yamamoto; Ken Kato; Yumiko Nakamura; Shizuo Akira; Kiyoshi Takeda; Yoshitaka Kajimoto; Yoshimitsu Yamasaki; Eric P Sandgren; Yoshiya Kawaguchi; Christopher V E Wright; Yoshio Fujitani
Journal:  Genes Dev       Date:  2006-06-01       Impact factor: 11.361

Review 2.  Pancreatic development and disease.

Authors:  David A Cano; Matthias Hebrok; Martin Zenker
Journal:  Gastroenterology       Date:  2007-02       Impact factor: 22.682

3.  Epithelial dynamics of pancreatic branching morphogenesis.

Authors:  Alethia Villasenor; Diana C Chong; Mark Henkemeyer; Ondine Cleaver
Journal:  Development       Date:  2010-12       Impact factor: 6.868

4.  Cdc42-mediated tubulogenesis controls cell specification.

Authors:  Gokul Kesavan; Fredrik Wolfhagen Sand; Thomas Uwe Greiner; Jenny Kristina Johansson; Sune Kobberup; Xunwei Wu; Cord Brakebusch; Henrik Semb
Journal:  Cell       Date:  2009-11-13       Impact factor: 41.582

5.  Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Authors:  Anna L Means; Kevin C Ray; Amar B Singh; M Kay Washington; Robert H Whitehead; Raymond C Harris; Christopher V E Wright; Robert J Coffey; Steven D Leach
Journal:  Gastroenterology       Date:  2003-04       Impact factor: 22.682

6.  In vitro cultivation of human islets from expanded ductal tissue.

Authors:  S Bonner-Weir; M Taneja; G C Weir; K Tatarkiewicz; K H Song; A Sharma; J J O'Neil
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

7.  Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.

Authors:  Andrew J Aguirre; Nabeel Bardeesy; Manisha Sinha; Lyle Lopez; David A Tuveson; James Horner; Mark S Redston; Ronald A DePinho
Journal:  Genes Dev       Date:  2003-12-17       Impact factor: 11.361

8.  Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.

Authors:  Meritxell Rovira; Sherri-Gae Scott; Andrew S Liss; Jan Jensen; Sarah P Thayer; Steven D Leach
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-15       Impact factor: 11.205

9.  Recovery from diabetes in mice by beta cell regeneration.

Authors:  Tomer Nir; Douglas A Melton; Yuval Dor
Journal:  J Clin Invest       Date:  2007-09       Impact factor: 14.808

10.  Mouse pancreatic acinar/ductular tissue gives rise to epithelial cultures that are morphologically, biochemically, and functionally indistinguishable from interlobular duct cell cultures.

Authors:  S Githens; J A Schexnayder; R L Moses; G M Denning; J J Smith; M L Frazier
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-09       Impact factor: 2.416
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  101 in total

1.  Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Authors:  Li Ding; Geou-Yarh Liou; Daniel M Schmitt; Peter Storz; Jin-San Zhang; Daniel D Billadeau
Journal:  J Pathol       Date:  2017-07-27       Impact factor: 7.996

2.  Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

Authors:  Hui-Lin Ye; Dou-Dou Li; Qing Lin; Yu Zhou; Quan-Bo Zhou; Bing Zeng; Zhi-Qiang Fu; Wen-Chao Gao; Yi-Min Liu; Rui-Wan Chen; Zhi-Hua Li; Ru-Fu Chen
Journal:  World J Gastroenterol       Date:  2015-06-07       Impact factor: 5.742

Review 3.  SP and KLF Transcription Factors in Digestive Physiology and Diseases.

Authors:  Chang-Kyung Kim; Ping He; Agnieszka B Bialkowska; Vincent W Yang
Journal:  Gastroenterology       Date:  2017-03-30       Impact factor: 22.682

Review 4.  Oncogenic KRAS and the EGFR loop in pancreatic carcinogenesis-A connection to licensing nodes.

Authors:  Christian Schneeweis; Matthias Wirth; Dieter Saur; Maximilian Reichert; Günter Schneider
Journal:  Small GTPases       Date:  2017-01-20

Review 5.  Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.

Authors:  Veronique Giroux; Anil K Rustgi
Journal:  Nat Rev Cancer       Date:  2017-09-01       Impact factor: 60.716

6.  KRAS mutation and epithelial-macrophage interplay in pancreatic neoplastic transformation.

Authors:  Faraz Bishehsari; Lijuan Zhang; Usman Barlass; Nailliw Z Preite; Sanja Turturro; Matthew S Najor; Brandon B Shetuni; Janet P Zayas; Mahboobeh Mahdavinia; Abde M Abukhdeir; Ali Keshavarzian
Journal:  Int J Cancer       Date:  2018-08-09       Impact factor: 7.396

7.  Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation.

Authors:  Neus Martínez-Bosch; Maite G Fernández-Barrena; Mireia Moreno; Elena Ortiz-Zapater; Jessica Munné-Collado; Mar Iglesias; Sabine André; Hans-Joachim Gabius; Rosa F Hwang; Françoise Poirier; Carolina Navas; Carmen Guerra; Martin E Fernández-Zapico; Pilar Navarro
Journal:  Cancer Res       Date:  2014-05-08       Impact factor: 12.701

8.  Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas.

Authors:  Irene Ischenko; Oleksi Petrenko; Michael J Hayman
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

9.  Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors.

Authors:  Markus Krausch; Feride Kroepil; Nadja Lehwald; Anja Lachenmayer; Matthias Schott; Martin Anlauf; Kenko Cupisti; Wolfram Trudo Knoefel; Andreas Raffel
Journal:  Endocrine       Date:  2012-12-07       Impact factor: 3.633

10.  Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study.

Authors:  Guido Carpino; Anastasia Renzi; Vincenzo Cardinale; Antonio Franchitto; Paolo Onori; Diletta Overi; Massimo Rossi; Pasquale Bartolomeo Berloco; Domenico Alvaro; Lola M Reid; Eugenio Gaudio
Journal:  J Anat       Date:  2015-11-27       Impact factor: 2.610
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