Literature DB >> 22132883

Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation.

B Brooks-Worrell1, J P Palmer.   

Abstract

Historically, the development of type 2 diabetes has been considered not to have an autoimmune component, in contrast to the autoimmune pathogenesis of type 1 diabetes. In this review we will discuss the accumulating data supporting the concept that islet autoreactivity and inflammation is present in type 2 diabetes pathogenesis, and the islet autoimmunity appears to be one of the factors associated with the progressive nature of the type 2 diabetes disease process. Published 2011. This article is a U.S. Government work and is in the public domain in the USA.

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Year:  2012        PMID： 22132883      PMCID： PMC3248085          DOI： 10.1111/j.1365-2249.2011.04501.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


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