OBJECTIVE: We aimed to assess spinal nociception and experimental pain sensitivity in progressive supranuclear palsy-Richardson's syndrome (PSP-R) compared to patients with Parkinson's disease (PD) and healthy controls (HC). METHODS: Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in non-demented, non-depressed, probable PSP-R patients (N = 8), PD patients (N = 19) and 17 HC. RESULTS: PSP-R patients exhibited lower electrical pain thresholds and a tendency for lower NFR thresholds as compared to HC. No significant differences between PSP-R and PD patients were found with respect to experimentally-induced pain. However, significantly less PSP-R than PD patients reported disease-related pain. CONCLUSIONS: Degeneration of the descending inhibitory control system within the brainstem in PSP-R might lead to increased experimental pain sensitivity while frontal cortical deterioration may alter self-estimation of pain.
OBJECTIVE: We aimed to assess spinal nociception and experimental pain sensitivity in progressive supranuclear palsy-Richardson's syndrome (PSP-R) compared to patients with Parkinson's disease (PD) and healthy controls (HC). METHODS: Spinal nociception as measured by the nociceptive flexion reflex (NFR) and experimental pain sensitivity as measured by heat and electrical pain thresholds were determined in non-demented, non-depressed, probable PSP-R patients (N = 8), PDpatients (N = 19) and 17 HC. RESULTS:PSP-R patients exhibited lower electrical pain thresholds and a tendency for lower NFR thresholds as compared to HC. No significant differences between PSP-R and PDpatients were found with respect to experimentally-induced pain. However, significantly less PSP-R than PDpatients reported disease-related pain. CONCLUSIONS: Degeneration of the descending inhibitory control system within the brainstem in PSP-R might lead to increased experimental pain sensitivity while frontal cortical deterioration may alter self-estimation of pain.
Authors: Evangelia Boura; Maria Stamelou; David Vadasz; Vincent Ries; Marcus M Unger; Georg Kägi; Wolfgang H Oertel; Jens C Möller; Veit Mylius Journal: J Neurol Date: 2017-01-24 Impact factor: 4.849
Authors: Lewis Kass-Iliyya; Christopher Kobylecki; Kathryn R McDonald; Alexander Gerhard; Monty A Silverdale Journal: Brain Behav Date: 2015-03-25 Impact factor: 2.708