Literature DB >> 22129752

Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae.

Tsutomu Takahashi1, Shingo Nakashima, Takuro Masuda, Shigehiro Yoneda, Gi-Wook Hwang, Akira Naganuma.   

Abstract

To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistance-related genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.

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Year:  2011        PMID: 22129752     DOI: 10.2131/jts.36.855

Source DB:  PubMed          Journal:  J Toxicol Sci        ISSN: 0388-1350            Impact factor:   2.196


  1 in total

1.  High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast.

Authors:  Ayse Banu Demir; Ahmet Koc
Journal:  PLoS One       Date:  2015-12-21       Impact factor: 3.240

  1 in total

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