Literature DB >> 2212945

Antibody raised against soluble CD4-rgp120 complex recognizes the CD4 moiety and blocks membrane fusion without inhibiting CD4-gp120 binding.

F Celada1, C Cambiaggi, J Maccari, S Burastero, T Gregory, E Patzer, J Porter, C McDanal, T Matthews.   

Abstract

We studied the humoral response of mice immunized with soluble CD4-rgp120 complex, testing polyclonal and monoclonal antibodies (mAbs) with the aim of identifying molecular changes that take place after the first interaction between human immunodeficiency virus and the cell surface. The antisera had a paradoxically high syncytia-blocking titer associated with anti-CD4 specificity, while their capacity to inhibit CD4-gp120 binding was relatively modest. One of the mAbs produced from these responders blocks syncytia formation but does not inhibit CD4 interaction with gp120. Apparently, this mAb interacts with the CD4 moiety of CD4-gp120 complex and prevents a post-binding event necessary for membrane fusion and viral infection.

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Year:  1990        PMID： 2212945      PMCID： PMC2188612          DOI： 10.1084/jem.172.4.1143

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  22 in total

1.  Constraints in T-B cooperation related to epitope topology on E. coli beta-galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation-dependent determinants.

Authors:  F Manca; A Kunkl; D Fenoglio; A Fowler; E Sercarz; F Celada
Journal:  Eur J Immunol       Date:  1985-04       Impact factor: 5.532

2.  Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion.

Authors:  T J Matthews; K J Weinhold; H K Lyerly; A J Langlois; H Wigzell; D P Bolognesi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

3.  Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor.

Authors:  L A Lasky; G Nakamura; D H Smith; C Fennie; C Shimasaki; E Patzer; P Berman; T Gregory; D J Capon
Journal:  Cell       Date:  1987-09-11       Impact factor: 41.582

4.  Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4.

Authors:  A Peterson; B Seed
Journal:  Cell       Date:  1988-07-01       Impact factor: 41.582

Review 5.  Antibody-induced conformational changes in proteins.

Authors:  F Celada; R Strom
Journal:  Q Rev Biophys       Date:  1972-08       Impact factor: 5.318

6.  Antibody-mediated activation of a defective beta-D-galactosidase extracted from an Escherichia coli mutant.

Authors:  M B Rotman; F Celada
Journal:  Proc Natl Acad Sci U S A       Date:  1968-06       Impact factor: 11.205

7.  Differential activation of T cell clones stimulated by macrophages exposed to antigen complexed with monoclonal antibodies. A possible influence of paratope specificity on the mode of antigen processing.

Authors:  F Manca; D Fenoglio; A Kunkl; C Cambiaggi; M Sasso; F Celada
Journal:  J Immunol       Date:  1988-05-01       Impact factor: 5.422

8.  T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.

Authors:  D Klatzmann; E Champagne; S Chamaret; J Gruest; D Guetard; T Hercend; J C Gluckman; L Montagnier
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

9.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

10.  Specificities of monoclonal and polyclonal antibodies that inhibit adsorption of herpes simplex virus to cells and lack of inhibition by potent neutralizing antibodies.

Authors:  A O Fuller; P G Spear
Journal:  J Virol       Date:  1985-08       Impact factor: 5.103
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  24 in total

1.  Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.

Authors:  S Lee; K Peden; D S Dimitrov; C C Broder; J Manischewitz; G Denisova; J M Gershoni; H Golding
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex.

Authors:  T R Fouts; R Tuskan; K Godfrey; M Reitz; D Hone; G K Lewis; A L DeVico
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques.

Authors:  Timothy Fouts; Karla Godfrey; Kathryn Bobb; David Montefiori; Carl V Hanson; V S Kalyanaraman; Anthony DeVico; Ranajit Pal
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-21       Impact factor: 11.205

4.  The human fibroblast receptor for gp86 of human cytomegalovirus is a phosphorylated glycoprotein.

Authors:  S Keay; B Baldwin
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

5.  Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

Authors:  C Terai; R S Kornbluth; C D Pauza; D D Richman; D A Carson
Journal:  J Clin Invest       Date:  1991-05       Impact factor: 14.808

6.  Reduced monomeric CD4 is the preferred receptor for HIV.

Authors:  Lisa J Matthias; Iman Azimi; Catherine A Tabrett; Philip J Hogg
Journal:  J Biol Chem       Date:  2010-10-25       Impact factor: 5.157

7.  Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.

Authors:  H Golding; D S Dimitrov; J Manischewitz; C C Broder; J Robinson; S Fabian; D R Littman; C K Lapham
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

Review 8.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03

9.  Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immunodeficiency virus-1 infection has the phenotypic appearance of an antigenically driven response.

Authors:  S Itescu; J Dalton; H Z Zhang; R Winchester
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

10.  Enhanced in vitro human immunodeficiency virus type 1 replication in B cells expressing surface antibody to the TM Env protein.

Authors:  Y Tani; E Donoghue; S Sharpe; E Boone; H C Lane; S Zolla-Pazner; D I Cohen
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103
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