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Literature DB >> 2212941

The autoantigen Ku is indistinguishable from NF IV, a protein forming multimeric protein-DNA complexes.

M H Stuiver¹, F E Coenjaerts, P C van der Vliet.

Abstract

We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was identified within the sequence of the small subunit of Ku. In addition, the proteins are identical in immunological aspects. We suggest that the Ku and NFIV proteins are identical. This connection adds new biochemical data to our knowledge of the Ku autoantigen.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1990 PMID： 2212941 PMCID： PMC2188621 DOI： 10.1084/jem.172.4.1049

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Purification of an 86-70 kDa nuclear DNA-associated protein complex.

Authors: M Yaneva; R Ochs; D K McRorie; S Zweig; H Busch
Journal: Biochim Biophys Acta Date: 1985-07-26

2. Mechanism of interaction between Ku protein and DNA.

Authors: T Mimori; J A Hardin
Journal: J Biol Chem Date: 1986-08-05 Impact factor: 5.157

3. Gene isolation by screening lambda gt11 libraries with antibodies.

Authors: R C Mierendorf; C Percy; R A Young
Journal: Methods Enzymol Date: 1987 Impact factor: 1.600

4. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

Authors: T Mimori; J A Hardin; J A Steitz
Journal: J Biol Chem Date: 1986-02-15 Impact factor: 5.157

5. Partial purification and properties of an exonuclease inhibitor induced by bacteriophage Mu-1.

Authors: J G Williams; C M Radding
Journal: J Virol Date: 1981-08 Impact factor: 5.103

6. A 10S particle released from deoxyribonuclease-sensitive regions of HeLa cell nuclei contains the 86-kilodalton-70-kilodalton protein complex.

Authors: M Yaneva; H Busch
Journal: Biochemistry Date: 1986-09-09 Impact factor: 3.162

7. Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

Authors: T Mimori; M Akizuki; H Yamagata; S Inada; S Yoshida; M Homma
Journal: J Clin Invest Date: 1981-09 Impact factor: 14.808

8. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex.

Authors: E de Vries; W van Driel; W G Bergsma; A C Arnberg; P C van der Vliet
Journal: J Mol Biol Date: 1989-07-05 Impact factor: 5.469

9. Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

Authors: T Mimori; Y Ohosone; N Hama; A Suwa; M Akizuki; M Homma; A J Griffith; J A Hardin
Journal: Proc Natl Acad Sci U S A Date: 1990-03 Impact factor: 11.205

10. Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots.

Authors: D E Smith; P A Fisher
Journal: J Cell Biol Date: 1984-07 Impact factor: 10.539

20 in total

1. Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.

Authors: J J Turchi; K M Henkels; Y Zhou
Journal: Nucleic Acids Res Date: 2000-12-01 Impact factor: 16.971

Review 2. B-cell epitopes of autoantigenic DNA-binding proteins.

Authors: C H Chou; M Satoh; J Wang; W H Reeves
Journal: Mol Biol Rep Date: 1992-06 Impact factor: 2.316

Review 3. B-cell epitopes of scleroderma-specific autoantigens.

Authors: R Verheijen
Journal: Mol Biol Rep Date: 1992-06 Impact factor: 2.316

Review 4. Autoantibodies against small cytoplasmic ribonucleoproteins: the anti-Ro/SS-A and anti-La/SS-B autoimmune response. A review of autoantibody detection, autoantigen composition, autoantibody-disease associations and possible etiologic mechanisms.

Authors: J F Meilof
Journal: Rheumatol Int Date: 1992 Impact factor: 2.631

5. Analysis of the mechanism of interaction of simian Ku protein with DNA.

Authors: S Paillard; F Strauss
Journal: Nucleic Acids Res Date: 1991-10-25 Impact factor: 16.971

6. Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.

Authors: G C Li; S H Yang; D Kim; A Nussenzweig; H Ouyang; J Wei; P Burgman; L Li
Journal: Proc Natl Acad Sci U S A Date: 1995-05-09 Impact factor: 11.205

7. A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats.

Authors: E L Beall; A Admon; D C Rio
Journal: Proc Natl Acad Sci U S A Date: 1994-12-20 Impact factor: 11.205

8. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

Authors: A Suwa; M Hirakata; Y Takeda; S A Jesch; T Mimori; J A Hardin
Journal: Proc Natl Acad Sci U S A Date: 1994-07-19 Impact factor: 11.205

9. Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens.

Authors: J Wang; C H Chou; J Blankson; M Satoh; M W Knuth; R A Eisenberg; D S Pisetsky; W H Reeves
Journal: Mol Biol Rep Date: 1993-06 Impact factor: 2.316

10. p95vav associates with the nuclear protein Ku-70.

Authors: F Romero; C Dargemont; F Pozo; W H Reeves; J Camonis; S Gisselbrecht; S Fischer
Journal: Mol Cell Biol Date: 1996-01 Impact factor: 4.272