BACKGROUND: An elevated thyroid stimulating hormone (TSH) level is a risk factor for differentiated thyroid cancer. The present study investigated whether TSH is a risk factor for thyroid microcarcinoma (TMC) in euthyroid subjects with a micronodule. METHODS: In this cross-sectional study, 483 euthyroid subjects (77 males patients, 406 females patients) with a thyroid micronodule were enrolled and underwent ultrasound guided fine-needle aspiration biopsy. Serum TSH level was measured in every subject. The final diagnostic outcome (malignant or benign) was defined in conjunction with cytology and histology. RESULTS: Compared with the patients below the population mean, patients above the population mean had a significantly higher malignancy rate (10.8% vs 4.8%, p = .025). Multiple logistic regression analysis revealed TSH as an independent risk factor for malignancy in euthyroid patients with a micronodule (odds ratio, 1.449; 95% confidence interval, 1.033-2.033; p = .031). CONCLUSIONS: Measurement of TSH in subjects with a thyroid micronodule is helpful to estimate cancer risk.
BACKGROUND: An elevated thyroid stimulating hormone (TSH) level is a risk factor for differentiated thyroid cancer. The present study investigated whether TSH is a risk factor for thyroid microcarcinoma (TMC) in euthyroid subjects with a micronodule. METHODS: In this cross-sectional study, 483 euthyroid subjects (77 males patients, 406 females patients) with a thyroid micronodule were enrolled and underwent ultrasound guided fine-needle aspiration biopsy. Serum TSH level was measured in every subject. The final diagnostic outcome (malignant or benign) was defined in conjunction with cytology and histology. RESULTS: Compared with the patients below the population mean, patients above the population mean had a significantly higher malignancy rate (10.8% vs 4.8%, p = .025). Multiple logistic regression analysis revealed TSH as an independent risk factor for malignancy in euthyroid patients with a micronodule (odds ratio, 1.449; 95% confidence interval, 1.033-2.033; p = .031). CONCLUSIONS: Measurement of TSH in subjects with a thyroid micronodule is helpful to estimate cancer risk.
Authors: Huang Huang; Jennifer Rusiecki; Nan Zhao; Yingtai Chen; Shuangge Ma; Herbert Yu; Mary H Ward; Robert Udelsman; Yawei Zhang Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-04-04 Impact factor: 4.254
Authors: Fanhua Zeng; Catherine Lerro; Jérôme Lavoué; Huang Huang; Jack Siemiatycki; Nan Zhao; Shuangge Ma; Nicole C Deziel; Melissa C Friesen; Robert Udelsman; Yawei Zhang Journal: Occup Environ Med Date: 2017-02-15 Impact factor: 4.402