Literature DB >> 22127

Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues.

S Y Cech, L J Ignarro.   

Abstract

Mammalian tissues possess the capacity to synthesize cytidine 3',5'-monopHosphate (cyclic CMP) via the enzymatic conversion of cytidine 5'-triphosphate to cyclic CMP by cytidylate cyclase. Cyclic CMP formation occurs best in the presence of manganese or iron, at neutral pH, at 37 degrees C, in the absence of detergents, and with whole tissue homogenate fractions. Thus, mammalian tissues are capable of synthesizing not only cyclic AMP and cyclic GMP, but also cyclic CMP.

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Year:  1977        PMID： 22127     DOI： 10.1126/science.22127

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Depression of cytidine 3':5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs.

Authors:  D M Helfman; N L Brackett; J F Kuo
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase.

Authors:  D B Mendel; T Cihlar; K Moon; M S Chen
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

3.  Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.

Authors:  Xiangang Zong; Stefanie Krause; Cheng-Chang Chen; Jens Krüger; Christian Gruner; Xiaochun Cao-Ehlker; Stefanie Fenske; Christian Wahl-Schott; Martin Biel
Journal:  J Biol Chem       Date:  2012-06-19       Impact factor: 5.157

4.  Extraction, purification, identification and metabolism of 3',5'-cyclic UMP, 3',5'-cyclic IMP and 3',5'-cyclic dTMP from rat tissues.

Authors:  R P Newton; E E Kingston; N A Hakeem; S G Salih; J H Beynon; C D Moyse
Journal:  Biochem J       Date:  1986-06-01       Impact factor: 3.857

5.  Cytidylate cyclase: development of assay and determination of kinetic properties of a cytidine 3',5'-cyclic monophosphate-synthesizing enzyme.

Authors:  R P Newton; B J Salvage; N A Hakeem
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857

6.  Extraction, purification and identification of cytidine 3',5'-cyclic monophosphate from rat tissues.

Authors:  R P Newton; S G Salih; B J Salvage; E E Kingston
Journal:  Biochem J       Date:  1984-08-01       Impact factor: 3.857

7.  Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.

Authors:  Andreas Hammerschmidt; Bijon Chatterji; Johannes Zeiser; Anke Schröder; Hans-Gottfried Genieser; Andreas Pich; Volkhard Kaever; Frank Schwede; Sabine Wolter; Roland Seifert
Journal:  PLoS One       Date:  2012-07-09       Impact factor: 3.240

8.  Analysis of substrate specificity and kinetics of cyclic nucleotide phosphodiesterases with N'-methylanthraniloyl-substituted purine and pyrimidine 3',5'-cyclic nucleotides by fluorescence spectrometry.

Authors:  Daniel Reinecke; Frank Schwede; Hans-Gottfried Genieser; Roland Seifert
Journal:  PLoS One       Date:  2013-01-14       Impact factor: 3.240
  8 in total

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