Literature DB >> 22126818

Target of γ-secretase modulators, presenilin marks the spot.

Christina J Crump1, Douglas S Johnson, Yue-Ming Li.   

Abstract

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Year:  2011        PMID： 22126818      PMCID： PMC3242977          DOI： 10.1038/emboj.2011.410

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


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  11 in total

1.  Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

Authors:  Dirk Beher; Earl E Clarke; Jonathan D J Wrigley; Agnes C L Martin; Alan Nadin; Ian Churcher; Mark S Shearman
Journal:  J Biol Chem       Date:  2004-08-10       Impact factor: 5.157

2.  Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

Authors:  Yu Ohki; Takuya Higo; Kengo Uemura; Naoaki Shimada; Satoko Osawa; Oksana Berezovska; Satoshi Yokoshima; Tohru Fukuyama; Taisuke Tomita; Takeshi Iwatsubo
Journal:  EMBO J       Date:  2011-10-14       Impact factor: 11.598

Review 3.  The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

Authors:  Eric Karran; Marc Mercken; Bart De Strooper
Journal:  Nat Rev Drug Discov       Date:  2011-08-19       Impact factor: 84.694

4.  Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

Authors:  Christina J Crump; Benjamin A Fish; Suita V Castro; De-Ming Chau; Natalya Gertsik; Kwangwook Ahn; Cory Stiff; Nikolay Pozdnyakov; Kelly R Bales; Douglas S Johnson; Yue-Ming Li
Journal:  ACS Chem Neurosci       Date:  2011-12-21       Impact factor: 4.418

5.  Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.

Authors:  Maria Z Kounnas; Anne M Danks; Soan Cheng; Curtis Tyree; Elizabeth Ackerman; Xulun Zhang; Kwangwook Ahn; Phuong Nguyen; Dan Comer; Long Mao; Chengzhi Yu; David Pleynet; Paul J Digregorio; Gonul Velicelebi; Kenneth A Stauderman; William T Comer; William C Mobley; Yue-Ming Li; Sangram S Sisodia; Rudolph E Tanzi; Steven L Wagner
Journal:  Neuron       Date:  2010-09-09       Impact factor: 17.173

6.  NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.

Authors:  Paul J Barrett; Charles R Sanders; Stephen A Kaufman; Klaus Michelsen; John B Jordan
Journal:  Biochemistry       Date:  2011-11-02       Impact factor: 3.162

7.  Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Authors:  Y M Li; M Xu; M T Lai; Q Huang; J L Castro; J DiMuzio-Mower; T Harrison; C Lellis; A Nadin; J G Neduvelil; R B Register; M K Sardana; M S Shearman; A L Smith; X P Shi; K C Yin; J A Shafer; S J Gardell
Journal:  Nature       Date:  2000-06-08       Impact factor: 49.962

8.  Novel γ-secretase enzyme modulators directly target presenilin protein.

Authors:  Amelie Ebke; Thomas Luebbers; Akio Fukumori; Keiro Shirotani; Christian Haass; Karlheinz Baumann; Harald Steiner
Journal:  J Biol Chem       Date:  2011-09-06       Impact factor: 5.157

9.  Substrate-targeting gamma-secretase modulators.

Authors:  Thomas L Kukar; Thomas B Ladd; Maralyssa A Bann; Patrick C Fraering; Rajeshwar Narlawar; Ghulam M Maharvi; Brent Healy; Robert Chapman; Alfred T Welzel; Robert W Price; Brenda Moore; Vijayaraghavan Rangachari; Bernadette Cusack; Jason Eriksen; Karen Jansen-West; Christophe Verbeeck; Debra Yager; Christopher Eckman; Wenjuan Ye; Sarah Sagi; Barbara A Cottrell; Justin Torpey; Terrone L Rosenberry; Abdul Fauq; Michael S Wolfe; Boris Schmidt; Dominic M Walsh; Edward H Koo; Todd E Golde
Journal:  Nature       Date:  2008-06-12       Impact factor: 49.962

10.  Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site.

Authors:  Kengo Uemura; Katherine C Farner; Tadafumi Hashimoto; Navine Nasser-Ghodsi; Michael S Wolfe; Edward H Koo; Bradley T Hyman; Oksana Berezovska
Journal:  Nat Commun       Date:  2010-11-30       Impact factor: 14.919
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  4 in total

Review 1.  γ-Secretase and its modulators: Twenty years and beyond.

Authors:  Weiming Xia
Journal:  Neurosci Lett       Date:  2019-02-11       Impact factor: 3.046

2.  Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.

Authors:  Giovanni Roti; Anne Carlton; Kenneth N Ross; Michele Markstein; Kostandin Pajcini; Angela H Su; Norbert Perrimon; Warren S Pear; Andrew L Kung; Stephen C Blacklow; Jon C Aster; Kimberly Stegmaier
Journal:  Cancer Cell       Date:  2013-02-21       Impact factor: 31.743

3.  Development of clickable active site-directed photoaffinity probes for γ-secretase.

Authors:  Christina J Crump; Christopher W am Ende; T Eric Ballard; Nikolay Pozdnyakov; Martin Pettersson; De-Ming Chau; Kelly R Bales; Yue-Ming Li; Douglas S Johnson
Journal:  Bioorg Med Chem Lett       Date:  2012-02-20       Impact factor: 2.823

Review 4.  The very many faces of presenilins and the γ-secretase complex.

Authors:  Michalina Smolarkiewicz; Tomasz Skrzypczak; Przemysław Wojtaszek
Journal:  Protoplasma       Date:  2013-03-16       Impact factor: 3.356
  4 in total

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